Efficacy and Safety of Non-Steroidal Anti-Inflammatory Drugs in Ureteral Colic: A Double-Blind Controlled Trial
The management of pain from ureteric colic (UC) has depended until now upon antispasmodic agents (AA) and, if ineffective, opiates. However, the high failure rate with AA and the risk attached to opiates makes this approach inadvisable. It has recently been proposed that UC be treated with indomethacin1, a nonsteroidal anti-inflammatory drug (NSAID), which inhibits PG biosynthesis thereby counteracting the effects of PGE2 on ureteric wall tone and glomerular filtration rate, both of which increase the pressure above the stone and evoke pain2,3.
KeywordsGlomerular Filtration Rate Pain Intensity High Failure Rate Complete Relief Italy Introduction
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