Clinical Manipulation of Urinary GAGS — A New Method of Stone Prevention (?)
Urinary polyanions are known to be potent inhibitors of calcium oxalate (CaOx) crystal growth and agglomeration1−3. These include glycosaminoglycans, ribonucleic acid and nonpolymerised Tamm-Horsfall mucoprotein2−4. The excretion of these macromolecules tends to be lower in the urine of recurrent CaOx stone-formers than in the urine of normal subjects4. Unfortunately, it has not so far been possible to increase this fraction in urine with a view to preventing the recurrence of CaOx stones.
KeywordsCrystallization Dioxide Cage Creatinine Heparin
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- 4.W. G. Robertson, A. B. Latif, D. S. Scurr, A. M. Caswell, G. W. Drach, and A. D. Randolph, in: “Urinary Stone”, R. Ryall, J. G. Brockis, V. Marshall, and B. Finlayson, eds., Churchill Livingstone, Melbourne (1984).Google Scholar