Clinical Manipulation of Urinary GAGS — A New Method of Stone Prevention (?)

  • R. W. Norman
  • D. S. Scurr
  • W. G. Robertson
  • M. Peacock
Conference paper

Abstract

Urinary polyanions are known to be potent inhibitors of calcium oxalate (CaOx) crystal growth and agglomeration1−3. These include glycosaminoglycans, ribonucleic acid and nonpolymerised Tamm-Horsfall mucoprotein2−4. The excretion of these macromolecules tends to be lower in the urine of recurrent CaOx stone-formers than in the urine of normal subjects4. Unfortunately, it has not so far been possible to increase this fraction in urine with a view to preventing the recurrence of CaOx stones.

Keywords

Crystallization Dioxide Cage Creatinine Heparin 

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References

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • R. W. Norman
    • 1
  • D. S. Scurr
    • 1
  • W. G. Robertson
    • 1
  • M. Peacock
    • 1
  1. 1.MRC Mineral Metabolism UnitThe General InfirmaryLeedsUK

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