The Inhibition of Experimental Nephrocalcinosis with A Prostaglandin Synthetase Inhibitor

  • A. C. Buck
Conference paper


Investigation into the pathognesis of idiopathic renal calculi has focused mainly on the physiochemical aspects of urinary crystallisation1−3. However, the presence of microscopic foci of intranephronic calcification suggests that the pathogenesis of stone formation begins within the interstitial tissues and the renal tubular cells, and it is this lesion which is regarded as the precursor of the calcium oxalate stone4−7. An explanation for the mechanism of stone formation should endeavour to relate the physico-chemical and anatomical concepts of calculogenesis.


Stone Formation Calcium Oxalate Interstitial Tissue Renal Tubular Cell Calcium Gluconate 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • A. C. Buck
    • 1
  1. 1.Dept. of UrologyThe Welsh National School of MedicineCardiffUK

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