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The Influence of Flurbiprofen on Calcium Excretion and Vitamin D3 in Recurrent Calcium Lithiasis — A Double Blind Study

  • A. C. Buck
  • C. J. Davies
  • R. Brown
  • R. Y. Sabur
  • K. Murray
Conference paper

Abstract

Idiopathic calcium stone formation occurs against a background of subtle abnormalities in the crystalloid composition of urine and poorly defined disorders of calcium metabolism. It is now recognised that hypercalciuria is a major predisposing “risk” factor in urolithiasis and in most cases it is secondary to calcium hyperabsorption. The vitamin D metabolite, 1,25-(OH)2D3, stimulates intestinal calcium absorption and bone resorption and 1,25(OH)2D3 levels are indeed raised in stone formers, although the factors responsible for this abnormality remain obscure. Recent in vitro experiments suggest that prostaglandins may regulate renal 1αhydroxylase activity synthesising 1,25-(OH)2D3. The aim of this study was to evaluate the effect of prostaglandin inhibition with Flurbiprofen on urinary calcium excretion and vitamin D3 metabolism in a selected group of recurrent idiopathic stone formers.

Keywords

Calcium Excretion Urinary Calcium Excretion Intestinal Calcium Absorption Idiopathic Hypercalciuria Renal Prostaglandin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. D. Wark, R. G. Larkins, J. A. Eisman, and K. R. Wilson, Clin. Sci. 61:53 (1981).PubMedGoogle Scholar
  2. 2.
    R. J. Walton and O. L. M. Bijvoet, Lancet 2:309 (1975).PubMedCrossRefGoogle Scholar
  3. 3.
    M. Peacock and B. E. C. Nordin, J. Clin. Path. 21:353 (1968).PubMedCrossRefGoogle Scholar
  4. 4.
    R. A. Kaplan, M. R. Haussier, L. J. Deftos, H. Bone, and C. Y. C. Pak, J. Clin. Invest. 59:756 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    F. H. Shen, D. J. Baylink, R. L. Mielsen, D. J. Sherrard, J. L. Ivey, and M. R. Haussier, J. Lab. Clin. Med. 90:955 (1977).PubMedGoogle Scholar
  6. 6.
    A. E. Broadus, R. L. Horst, R. Lang, E. T. Littledike, and H. Rasmussen, New Engl. J. Med. 302:421 (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    M. Garabedian, M. F. Holick, H. F. DeLuca, and I. T. Boyle, Proc. Nat. Acad. Sci. 69:1673 (1972).PubMedCrossRefGoogle Scholar
  8. 8.
    Y. Tanaka and H. F. DeLuca, Proc. Nat. Acad. Sci. 71:1040 (1974).PubMedCrossRefGoogle Scholar
  9. 9.
    H. F. DeLuca, and H. K. Schnoes, Ann. Rev. Biochem. 45: 631 (1976).PubMedCrossRefGoogle Scholar
  10. 10.
    J. Lemann, in: “Contemporary Issues in Nephrology”, F. L. Coe, B. M. Brenner, and J. H. Stein, eds., Churchill Livingstone, New York (1980).Google Scholar
  11. 11.
    M. J. Dunn and V. L. Hood, Am. J. Physiol. 233:F169 (1977).Google Scholar
  12. 12.
    A. C. Buck, C. J. Lote, and W. F. Sampson, J. Urol. 129:421 (1983).PubMedGoogle Scholar
  13. 13.
    B. Ettinger, Am. J. Med. 61:200 (1976).PubMedCrossRefGoogle Scholar
  14. 14.
    M. J. V. Smith, J. Urol. 117:690 (1977).PubMedGoogle Scholar
  15. 15.
    P. Brocks, C. Dahl, H. Woolf, and I. Transbøl, Lancet 2:124 (1981).PubMedCrossRefGoogle Scholar
  16. 16.
    D. H. Hosking, S. B. Ericson, C. J. Van den Berg, D. M. Wilson, and L. H. Smith, J. Urol. 130:1115 (1983).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • A. C. Buck
    • 1
  • C. J. Davies
    • 1
  • R. Brown
    • 1
  • R. Y. Sabur
    • 1
  • K. Murray
    • 1
  1. 1.Dept. of UrologyWelsh National School of MedicineCardiffUK

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