The Influence of Flurbiprofen on Calcium Excretion and Vitamin D3 in Recurrent Calcium Lithiasis — A Double Blind Study
Idiopathic calcium stone formation occurs against a background of subtle abnormalities in the crystalloid composition of urine and poorly defined disorders of calcium metabolism. It is now recognised that hypercalciuria is a major predisposing “risk” factor in urolithiasis and in most cases it is secondary to calcium hyperabsorption. The vitamin D metabolite, 1,25-(OH)2D3, stimulates intestinal calcium absorption and bone resorption and 1,25(OH)2D3 levels are indeed raised in stone formers, although the factors responsible for this abnormality remain obscure. Recent in vitro experiments suggest that prostaglandins may regulate renal 1αhydroxylase activity synthesising 1,25-(OH)2D3. The aim of this study was to evaluate the effect of prostaglandin inhibition with Flurbiprofen on urinary calcium excretion and vitamin D3 metabolism in a selected group of recurrent idiopathic stone formers.
KeywordsCalcium Excretion Urinary Calcium Excretion Intestinal Calcium Absorption Idiopathic Hypercalciuria Renal Prostaglandin
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