Drugs Against Kidney Stones: Effects of Magnesium and Alkali
During the 1920s it was reported that magnesium was able to increase the solubility of calcium oxalate in vitro and it was proposed that magnesium could be used in the prevention of kidney stones. Rats fed on a diet low in magnesium developed kidney stones within a short time. Precipitation, particularly of calcium phosphate (hydroxyapatite) crystals, occurred in the proximal tubules. This could also be achieved by feeding rats a diet deficient in vitamin B6; but if at the same time the diet was supplemented with magnesium this prevented stone formation1,2.
KeywordsKidney Stone Calcium Oxalate Stone Disease Calcium Excretion Renal Tubular Acidosis
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