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The Effect of Long-Term Treatment with Allopurinol on Stone Recurrence in Calcium Urolithiasis

  • B. Ulshöfer
  • J. Zenke
  • W. Achilles
  • G. Rodeck
Conference paper

Abstract

The role of uric acid (UA) in calcium lithiasis is not yet understood1, but some clinical studies suggest that reducing UA excretion has a prophylactic effect on stone recurrence2. The results of allopurinol treatment are as varied as the indications for using it (hyperuricosuria2, hyperuricemia3, idiopathic calcium stone disease4). The decrease of UA in serum and urine, which seems to be the only effect of allopurinol, depends on the values prior to treatment, i.e. the higher the value before treatment, the greater the decrease during treatment5. The aim of the study was to evaluate whether or not potential treatment failures can be recognized from their biochemistry before treatment commences and how they differ from responders when stones recur.

Keywords

Uric Acid Prophylactic Effect Stone Recurrence Excessive Calcium Uric Acid Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    B. Finlayson, in: “Urolithiasis and Related Clinical Research”, P. O. Schwüle, L. H, Smith, W. G. Robertson, and W. Vahlensieck, eds., Plenum, New York (1985).Google Scholar
  2. 2.
    F. L. Coe, Kidney Int. 13:418 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    M. J. V. Smith, J. Urol. 117:690 (1977).PubMedGoogle Scholar
  4. 4.
    W. G. Robertson, M. Peacock, P. L. Selby, R. E. Williams, P. Clark, G. D. Chisholm, T. B. Hargreave, M. B. Rose, H. Wilkinson, D. C. Hammonds, and W. J. Gall, in: “Urolithiasis and Related Clinical Research, P. O. Schwüle, L. H. Smith, W. G. Robertson, and W. Vahlensieck, eds., Plenum, New York (1985).Google Scholar
  5. 5.
    B. Ulshöfer, Akt. Urol. 15: (in press) (1984).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • B. Ulshöfer
    • 1
  • J. Zenke
    • 1
  • W. Achilles
    • 1
  • G. Rodeck
    • 1
  1. 1.Urologische Universitätsklinik und Poliklinik MarburgMarburg a.d. LahnGermany

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