The Effect of Long-Term Treatment with Allopurinol on Stone Recurrence in Calcium Urolithiasis
The role of uric acid (UA) in calcium lithiasis is not yet understood1, but some clinical studies suggest that reducing UA excretion has a prophylactic effect on stone recurrence2. The results of allopurinol treatment are as varied as the indications for using it (hyperuricosuria2, hyperuricemia3, idiopathic calcium stone disease4). The decrease of UA in serum and urine, which seems to be the only effect of allopurinol, depends on the values prior to treatment, i.e. the higher the value before treatment, the greater the decrease during treatment5. The aim of the study was to evaluate whether or not potential treatment failures can be recognized from their biochemistry before treatment commences and how they differ from responders when stones recur.
KeywordsUric Acid Prophylactic Effect Stone Recurrence Excessive Calcium Uric Acid Excretion
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