Advertisement

Further Reduction of Oxalate Excretion by Allopurinol in Stone Formers on Low Purine Diet

  • B. Tomlinson
  • S. L. Cohen
  • A. Al-Khader
  • G. P. Kasidas
  • G. A. Rose

Abstract

Allopurinol may reduce calcium oxalate stone formation. Small elevations in urine oxalate are implicated in calculus production and increased dietary purine increases oxalate excretion1. Oxalate excretion has been reduced by allopurinol in some stone formers2 but trials have been complicated by variations in oxalate excretion with changes in diet and doubts over oxalate methodology. Preliminary studies have shown that allopurinol reduced urine oxalate in normal subjects and the effect was greater with a high purine intake.

Keywords

Calcium Oxalate Calcium Excretion Urinary Oxalate Oxalate Excretion Urinary Oxalate Excretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. M. Zarembski and A. Hodgkinson, Clin. Chim. Acta. 25:1 (1969).PubMedCrossRefGoogle Scholar
  2. 2.
    R. Scott, A. Mathieson, and A. McLelland, Br. J. Urol. 50:455 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    H. A. Simmonds, K. J. Van Acker, C. F. Potter, D. R. Webster, G. P. Kasidas, and G. A. Rose, in: “Urolithiasis:Clinical and Basic Research”, L. H. Smith, W. G. Robertson, and B. Finlayson, eds., Plenum, New York (1981).Google Scholar
  4. 4.
    P. C. Hallson and G. A. Rose, Clin. Chim. Acta 55:29 (1974).PubMedCrossRefGoogle Scholar
  5. 5.
    G. P. Kasidas and G. A. Rose, Clin. Chim. Acta 96:25 (1979).PubMedCrossRefGoogle Scholar
  6. 6.
    C. Y. C. Pak, D. E. Barilla, K. Holt, L. Brinkley, R. Tolentino, and J. E. Zerwekh, Am. J. Med. 65:593 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    A. M. Finch, G. P. Kasidas, and G. A. Rose, Clin. Sci. 60(4):411 (1981).PubMedGoogle Scholar
  8. 8.
    R. W. Marshall, M. Cochran, and A. Hodgkinson, Clin. Sci. 43:91 (1972).PubMedGoogle Scholar
  9. 9.
    T. B. Hargreave, A. Sali, C. Mackay, and M. Sullivan, Br. J. Urol. 49:597 (1977).PubMedCrossRefGoogle Scholar
  10. 10.
    F. L. Coe, Kidney Int. 13:418 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • B. Tomlinson
    • 1
  • S. L. Cohen
    • 1
  • A. Al-Khader
    • 1
  • G. P. Kasidas
    • 1
  • G. A. Rose
    • 1
  1. 1.Dept. of Medicine, University College, Dept. of Chemical PathologySt. Peter’s Hospital, and Institute of UrologyLondonUK

Personalised recommendations