Appraisal of Methodology in Studies of Either Thiazide or Orthophosphate Therapy for Recurrent Calcium Urolithiasis
Thiazide diuretics and orthophosphates are generally considered effective in the prevention of recurrent calcium urolithiasis but several randomized controlled clinical trials have failed to demonstrate this effectiveness13–15. These different conclusions may, in part, be explained by the various clinical research designs used. In order to evaluate this, clinical trials using these drugs to prevent recurrent calcium urolithiasis were examined from the viewpoint of clinical research methodology.
KeywordsControl Clinical Trial Group Design Thiazide Diuretic Stone Recurrence Significant Clinical Effect
Unable to display preview. Download preview PDF.
- 3.L. H. Smith, W. C. Thomas, and C. D. Arnaud, in: “Urinary Calculi”, L. Cifuentes Delatte, A. Rapado, and A. Hodgkinson, eds., Karger, Basel (1973).Google Scholar
- 7.M. Peacock, W. G. Robertson, P. J. Heyburn, A. E. J. Davies, and A. Rutherford, in: “Urolithiasis, Clinical and Basic Research”, L. H. Smith, W. G. Robertson, and B. Finlayson, eds., Plenum, New York (1981).Google Scholar
- 11.S. Ljunghall, U. Backman, B. G. Danielson, B. Fellstrom, G. Johansson, and B. Wikström, in: “Urolithiasis, Clinical and Basic Research”, L. H. Smith, W. G. Robertson, and B. Finlayson, eds., Plenum, New York (1981).Google Scholar