Appraisal of Methodology in Studies of Either Thiazide or Orthophosphate Therapy for Recurrent Calcium Urolithiasis

  • D. N. Churchill
Conference paper


Thiazide diuretics and orthophosphates are generally considered effective in the prevention of recurrent calcium urolithiasis but several randomized controlled clinical trials have failed to demonstrate this effectiveness13–15. These different conclusions may, in part, be explained by the various clinical research designs used. In order to evaluate this, clinical trials using these drugs to prevent recurrent calcium urolithiasis were examined from the viewpoint of clinical research methodology.


Control Clinical Trial Group Design Thiazide Diuretic Stone Recurrence Significant Clinical Effect 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • D. N. Churchill
    • 1
  1. 1.Faculty of Health SciencesMcMaster UniversityHamiltonCanada

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