Thiazide Prophylaxis of Urolithiasis: A Double Blind Study in General Practice
Since 1970 several clinical trials using thiazides have been performed — all showing a substantial reduction in the rate of stone recurrence1–4. The following objections, however, can be made against these studies. There were no adequate control groups and/or randomization, and the double blind technique and placebo comparison were not applied except in one case5. No prospective study has been reported on the treatment of the different types of urolithiasis in general practice. The present study was conducted to investigate, in recurrent calcium stone formers, the prophylactic long-term effect of hydrochlorothiazide versus placebo in a randomized double blind trial in general practice, and to see if the outcome of treatment is related to pre-treatment urinary calcium and uric acid excretion.
KeywordsUric Acid Calcium Oxalate Stone Recurrence Meier Plot High Salt Intake
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