Epidemiology of Urolithiasis and Calcium Metabolism in Human Diabetes Mellitus
It has been shown in man1 and dogs2 that, in the presence of a constant blood glucose level, administration of insulin results in an exaggerated urinary excretion of calcium and increased tubular reabsorption of phosphorus. In the diabetic state (established insulin deficiency) the hypocalciuric effect of insulopenia counteracts the hypercalciuric effect of glucose-induced osmotic diuresis3. In the present epidemiological study the prevalence of urolithiasis and hypercalciuria have been determined in diabetics and controls.
KeywordsUrinary Calcium Stone Disease Calcium Excretion Tubular Reabsorption Experimental Diabetes Mellitus
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