Psychogenesis, Stress, Immunity and Cancer Etiology and Prognosis: Discussion of Dr. Fox’s Paper
Although the etiology of most childhood cancers remains elusive, pediatric oncologists find themselves in the paradoxical situation of having effective therapy at hand for about 50% of all malignancies that afflict children. Thus, we are curing leukemia and osteogenic sarcoma before we have a clue as to the cause. That statement isn’t entirely accurate because we are now aware of a number of associated genetic conditions, immune deficiency states (Kersey et al., 1973), chromosomal abnormalities, congenital malformations (Bolande, 1977), and environmental events that may predispose a child to cancer or significantly increase the risk of developing a malignancy. Foremost on the list of predisposing causes are such diverse disorders as (1) aniridia-Wilms* tumor syndrome; (2) chromosomal instability syndromes (Fanconi1s anemia, Bloom’s syndrome, ataxia-telangiectasia) and leukemia; (3) 21-tri-somy and leukemia; (4) immune deficiency diseases (severe combined immune deficiency disease (SCID), Wiskott-Aldrich syndrome, ataxia-telangiectasia and lymphoma; and (5) multimodality therapy (alkylating agents and radiation therapy) in Hodgkin’s disease or non-Hodgkin’s lymphoma followed by a second malignant neoplasm, acute non-lymphocytic leukemia.
KeywordsChildhood Cancer Primary Immunodeficiency Disease Psychogenic Factor Immune Deficiency State Pediatric Outpatient Department
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