Advertisement

Damage to the Developing Brain and Subtle Psychiatric Consequences: Implications of the Case of Milton: Discussion of Dr. Christ’s Paper

  • Mark Press
Part of the The Downstate Series of Research in Psychiatry and Psychology book series (DSRPP, volume 5)

Abstract

Dr. Christ has focused our attention on a problem of central importance, not only in the treatment of childhood malignancies, but in the broader field of psychiatry and human behavior. American psychiatry and psychology have tended to neglect the role of the neural substrate in behavior and affect. The case of Milton is a beautiful illustration of the role that insult to the central nervous system (CNS) may play, both directly and indirectly, in influencing psychological function, and of how even well-trained clinicians may ignore it as a result of their theoretical preconceptions.

Keywords

Acute Lymphocytic Leukemia Pediatric Oncology Childhood Malignancy Central Nervous System Leukemia American Psychiatry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allen, J. C., Deck, M. D. F., Howieson, J. and Brown, M. CT scans of long-term survivors of various childhood malignancies. Medical and Pediatric Oncology, 1981, 9, 109–117.PubMedCrossRefGoogle Scholar
  2. Ch’ien, L. T., Aur, R. J.A., Verzosa, M., Coburn, T. P., Goff, J. R., Hustie, H. O., Prince, R. A., Seifert, M. J. & Simone, J. V. Progression of Methotrexate induced leukoencephalopathy in children with leukemia. Medical and Pediatric Oncology, 1981, 9, 133–141.PubMedCrossRefGoogle Scholar
  3. Eiser, C. & Lansdown, R. Retrospective study of intellectual development in children treated for acute lymphoblastic leukemia. Archives of Disease in Childhood, 1977, 52, 525–529.PubMedCrossRefGoogle Scholar
  4. Eisseltine, D. W., Freeman, C. R., Chevalier, L. M., Smith, R., O’Gorman, A. M., Dube, J., Whitehead, V. M. & Nogrady, M. B. Computed tomography brain scans in long term survivors of childhood acute lymphoblastic leukemia. Medical and Pediatric Oncology, 1981, 9, 429–439.CrossRefGoogle Scholar
  5. Furchtgott, E. Ionizing radiations and the nervous system. In: G. E. Gaull (Ed.), Biology of Brain Dysfunction (Vol. 3). New York: Plenum Press, 1975.Google Scholar
  6. Goff, J. R., Anderson, H. R. Jr. & Cooper, P. F. Distractibility and memory deficits in long-term survivors of acute lymphoblastic leukemia. Journal of Developmental and Behavioral Pediatrics, 1980, 1, 158–163.PubMedCrossRefGoogle Scholar
  7. Kay, H. E. M., Knapton, P. J., O’Sullivan, J. P., Wells, D. G., Harris, R. F., Innes, E. M., Stuart, J., Schwartz, F. C. M. & Thompson, E. N. Encephalopathy in acute leukemia associated with methotrexate therapy. Archives of Disease in Childhood, 1972, 47, 344–354.PubMedCrossRefGoogle Scholar
  8. Meadows, A. T., Massari, D. J., Fergusson, J., Gordon, J., Littman, P. & Moss, K. Declines in IQ scores and cognitive dysfunctions in childhood with acute lymphocytic leukemia treated with cranial irrodiation. Lancet, November 7, 1981, 2 (Issue 8254) 1015–1018.PubMedCrossRefGoogle Scholar
  9. Moss, H. A., Nannes, E. D. & Poplack, D. G. The effects of prophylactic treatment of the central nervous system on the intellectual functioning of children with acute lymphocytic leukemia. American Journal of Medicine, 1981, 71, 47–52.PubMedCrossRefGoogle Scholar
  10. Pizzo, P. A., Poplack, D. G. & Bleyer, W. A. Neurotoxicities of current leukemia therapy. American Journal of Pediatric Hematology/Oncology, 1979, 1, 119–126.Google Scholar
  11. Price, R. A. & Jamieson, P. A. The central nervous system in childhood leukemia: II subacute leukoencephalopathy. Cancer, 1975, 35, 306–318.PubMedCrossRefGoogle Scholar
  12. Silberfarb, P. M., Philibert, D. & Levine, P. M. Psychosocial aspects of neoplastic disease: II affective and cognitive effects of chemotherapy in cancer patients. American Journal of Psychiatry, 1980, 137, 597–601.PubMedGoogle Scholar
  13. Soni, S. S., Marten, G. W., Pitner, S. E., Duenes, D. A. & Powazek, M. Effects of central nervous system irradiation on neuropsychologic functioning of children with acute lymphocytic leukemia. New England Journal of Medicine, 1975, 293, 113–118.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Mark Press
    • 1
  1. 1.Downstate Medical CenterBrooklynUSA

Personalised recommendations