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Light and Membrane Biogenesis in Rod Photoreceptors of Vertebrates

  • Joseph C. Besharse

Abstract

Throughout the life of an individual, retinal visual cells carry on an elaborate process of photosensitive membrane turnover which is at once prodigious and exquisitely adapted to maintenance of optimal function. The magnitude of the phenomenon, first defined in detail by the work of R. W. Young (1), can best be appreciated by realizing that rod outer segments of rodents are renewed entirely within a period of 10 to 12 days. During this period, outer segment dimensions in adult animals remain stable through the establishment of a balance between synthetic and degradative functions (2). Synthesis of photosensitive membrane precursors occurs in the cell body (inner segment) after which they are transported to the base of the outer segment for incorporation into membrane discs (3, 4). Ultimately, discs are degraded within the lysosomal system of retinal pigment epithelial cells (5, 6).

Keywords

Outer Segment Visual Pigment Open Disc Light Effect Intramembranous Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1980

Authors and Affiliations

  • Joseph C. Besharse
    • 1
  1. 1.Department of AnatomyEmory University School of MedicineAtlantaUSA

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