Damaging Effects of Constant Light and Darkness on the Retina of the Frog
Since the discovery of Noell (1) that continuous light of moderate intensity causes severe damage to the albino rat retina, the effects of constant light on retinal structure and function has been the subject of numerous investigations in a variety of animals including man (recently reviewed by Lanum, 2). Most of these studies have dealt with the temporal aspects of light damage to the photoreceptor layer, the cell type most severely affected by this treatment. Though light damage to the retina in pigmented animals has also been reported, in general higher intensity and/or longer duration of exposure are required and the severity of the damage is not as pronounced as in albino strains. Studies in several laboratories indicate that monochromatic light causes specific destruction of selected cone types in pigmented animals and suggests that light damage may be mediated by photopigments (3, 4).
KeywordsPigment Epithelium Retinal Cell Constant Light Constant Darkness Photoreceptor Layer
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