Membrane Turnover in Rod Outer Segments: Changing Patterns of Shedding after Extended Periods of Constant Light and Darkness
The suggestion of Bairati and Orzalesi (1) that the dense bodies in the pigment epithelium resembled fragments of outer segment material was experimentally established in the autoradiographic studies of Young and Bok (2). The latter investigators followed packets of radioactive outer segment membranes as they were shed from the outer segment tips and phagocytized by the pigment epithelium. Their studies clearly demonstrated that the dense bodies were of rod origin and pointed to an important role for the pigment epithelium in the rod outer segment renewal process.
KeywordsPigment Epithelium Outer Segment Constant Light Cyclic Light Constant Dark
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