Abstract
Since the isolation of the hormone gastrin as a pair of hepta-decapeptide amides from hog antral mucosa1, a great deal more has been learned about the various forms of the hormone which are to be found in the tissues of origin (antral and upper intestinal mucosa and gastrinomas) and in the circulation in normal and pathological conditions. The heterogeneity of tissue gastrin raises the important question of metabolic relationships in terms of the mechanism of biosynthesis, while heterogeneity in the circulation give rise to the equally important problem of determining the various forms separately by radioimmunoassay and of evaluating their respective contributions to the stimulation of target organs.
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References
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© 1978 Plenum Press, New York
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Gregory, R.A. (1978). The Gastrins: Structure and Heterogeneity. In: Grossman, M., Speranza, V., Basso, N., Lezoche, E. (eds) Gastrointestinal Hormones and Pathology of the Digestive System. Advances in Experimental Medicine and Biology, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7248-6_9
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DOI: https://doi.org/10.1007/978-1-4684-7248-6_9
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