The Gastrins: Structure and Heterogeneity

  • R. A. Gregory
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


Since the isolation of the hormone gastrin as a pair of hepta-decapeptide amides from hog antral mucosa1, a great deal more has been learned about the various forms of the hormone which are to be found in the tissues of origin (antral and upper intestinal mucosa and gastrinomas) and in the circulation in normal and pathological conditions. The heterogeneity of tissue gastrin raises the important question of metabolic relationships in terms of the mechanism of biosynthesis, while heterogeneity in the circulation give rise to the equally important problem of determining the various forms separately by radioimmunoassay and of evaluating their respective contributions to the stimulation of target organs.


Parathyroid Adenoma Gastrointestinal Hormone Antral Mucosa Ciba Foundation Symposium Aminoacid Residue 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • R. A. Gregory
    • 1
  1. 1.Physiological LaboratoryUniversity of LiverpoolLiverpoolEngland

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