Histamine H2-Receptors and Gastric Secretion
In 1966 Ash and Schild1 pointed out for the first time the existence of different types of histamine receptors. They defined as H1 receptors those which could be blocked by the classical antihistaminics and non-H1 receptors those which could not be blocked. However, a real milestone in the history of histamine was represented by the paper of Black and coworkers2 entitled “Definition and antagonism of histamine H2 receptors” in which the first H2 receptor antagonist, burimamide, was described. The subsequent availability of rather selective H2 receptor stimulants and inhibitors, which served as a tool for characterizing H1 and H2 receptors, contributed noticeably to clarifying the role of histamine in gastric secretion.
KeywordsGastric Secretion Methyl Histamine Oxyntic Cell High Maximal Rate Rabbit Trachea
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