Peptidergic Innervation of the Gastrointestinal Tract

  • J. M. Polak
  • S. R. Bloom
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


The presence of peptides in gut endocrine cells has been recognised for more than a decade but only in the last few years has it become increasingly apparent that several of these peptides are also found in the central and autonomic nervous system. In fact, the recognition that peptides can occur in at least 2 types of tissue is considerably older and dates from the discovery1 that the same peptide (substance P) could be extracted from both brain and gut. The list of these peptides found in both brain and gut is probably not yet complete but at present comprises VIP, CCK/ gastrin, neurotensin, somatostatin, bombesin, substance P, and enkephalin. In the gut mucosa these peptides may be found either in typical endocrine cells, where they may act as circulating or local hormones, or in the autonomic nerves. Here they may function as neurotransmitters or they may modify the responses of other cells by stimulation or inhibition.


Endocrine Cell Myenteric Plexus Hypertrophic Pyloric Stenosis Peptidergic Neuron Peptidergic Nerve 


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  1. 1.
    Euler US von, Gaddum JH: An unidentified depressor substance in certain tissue extracts. J. Physiol. (Lond.) 192: 74–87, 1931Google Scholar
  2. 2.
    Zetler G: The peptidergic neuron — a working hypothesis. Biochem. Pharmacol. 25: 1817–1818, 1976PubMedCrossRefGoogle Scholar
  3. 3.
    Hökfelt T, Schultzberg M, Johansson O, Ljungdahl A, Elfvin L, Elde R, Terenius L, Nilsson G, Said S, Goldstein M: Central and peripheral peptide producing neurons. In: Gut Hormones, edited by SR Bloom, Churchill Livingstone, Edinburgh, 1978, p. 423–433Google Scholar
  4. 4.
    Dodgiel AS: Über der bau der ganglien in den geflechten des darmes under der gallenblase des menschen U. der Säugetiere. Arch. f. Anat. u. Phys. Anat. Abth., 1899Google Scholar
  5. 5.
    Baumgarten HG, Holstein AF, Owman Ch: Auerbach’s plexus of mammals and man — electron microscopical identification of three different types of neuronal processes in myenteric ganglia of the large intestine from rhesus monkeys, guinea-pigs and man. Z. Zellsforsch 106: 376–397, 1970CrossRefGoogle Scholar
  6. 6.
    Bishop A, Polak, JM, Buchan AMJ, Bloom SR, Pearse AGE: A third division of the autonomic nervous system. An important element in gut control. Gut 18: A416, 1977Google Scholar
  7. 7.
    Burnstock G: Purinergic nerves. Pharmacol, Rev, 24: 509–581, 1972Google Scholar
  8. 8.
    Bloom SR, Polak JM: Peptidergic versus purinergic. The Lancet I: 93, 1978CrossRefGoogle Scholar
  9. 9.
    Pearse AGE: Common cytochemical properties of cells producing polypeptide hormones, with particular reference to calcitonin and the thyroid C cells. Vet. Rec. 79: 587–590, 1966PubMedCrossRefGoogle Scholar
  10. 10.
    Pearse AGE, Takor Takor T: Neuroendocrine embryology and the APUD concept. Clin. Endocrinol. 5 (suppl.): 229–234, 1976CrossRefGoogle Scholar
  11. 11.
    Feyrter F: Über diffuse endokrine epitheliale organe. J. A. Barth, Leipzig, 1938, p. 6–17Google Scholar
  12. 12.
    Pearse AGE, Polak JM: Bifunctional reagents as vapour- and liqui’d-phase fixatives for immunohistochemistry. Histochem. J. 7: 179–186, 1975PubMedCrossRefGoogle Scholar
  13. 13.
    Bishop AE, Polak JR, Bloom SR, Pearse AGE: A new universal technique for the immunocytochemical localisation of peptidergic innervation. J. Endocrinol., in pressGoogle Scholar
  14. 14.
    Sternberger L: The unlabelled antibody enzyme method. Prentice Hall Engelwood Cliff, 1974, p. 142–161Google Scholar
  15. 15.
    Polak JM, Sullivan SN, Bloom SR, Facer P, Pearse AGE: Enkephalin-like immunoreactivity in the human gastrointestinal tract. The Lancet I: 972–974, 1977CrossRefGoogle Scholar
  16. 16.
    Solcia E, Polak JM, Pearse AGE, Forssman WG, Larsson LI, Sundler F, Lechago J, Grimelius L, Fujita T, Creutzfeldt W, Gepts W, Falkmer S, LeFranc G, Heitz P, Hage E, Buchan AMJ, Bloom SR, Grossman MI: Lausanne 1977 classification of gastroenteropancreatic endocrine cells. In: Gut Hormones, edited by SR Bloom, Churchill Livingstone, Edinburgh, 1978, p. 40–48Google Scholar
  17. 17.
    Pearse AGE, Polak JM: Immunocytochemical localisation of substance P in mammalian intestine. Histochemistry 41: 373–375, 1975PubMedCrossRefGoogle Scholar
  18. 18.
    Hokfelt T, Elfvin LG, Elde R, Schultzberg M, Goldstein M, Luft R: Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons. Proc. Natl. Acad. Sci. USA 74: 3587–3591, 1977PubMedCrossRefGoogle Scholar
  19. 19.
    Arimura A, Coy DH, Chihara M, Fernandez-Durango R, Samols E, Chihara K, Meyers CA, Schally AV: Somatostatin. In: Gut Hormones, edited by SR Bloom, Churchill Livingstone, Edinburgh, 1978, p. 437–445Google Scholar
  20. 20.
    Ganda OmP, Weir GC, Soeldner JS, Legg MA, Chick WL, Patel YC, Ebeid AM, Gabbay KH, Reichlin S: Somatostatinoma — A somatostatin-containing tumour of the endocrine pancreas, N. Engl. J. Med. 296: 963–967, 1977PubMedCrossRefGoogle Scholar
  21. 21.
    Larsson LI, Hirsch MA, Holst JJ, Ingemansson S, Kuhl C, Jensen SL, Lundqvist G, Rehfeld JF: Pancreatic somatostatinoma — Clinical features and physiological implications, Lancet I: 66–668, 1977Google Scholar
  22. 22.
    Polak JM, Bloom SR: The endocrine background. Scientific Foundations of Gastroenterology, edited by W Sizcus and AN Smith, Williams Heineman Medical Books, 1978Google Scholar
  23. 23.
    Bryant MG, Bloom SR, Polak JM, Albuquerque RH, Modlin I, Pearse AGE: Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. The Lancet I: 991–994, 1976CrossRefGoogle Scholar
  24. 24.
    Verner JV, Morrison AB: Endocrine pancreatic islet disease with diarrhoea. Arch, Intern. Med, 133: 492–500, 1958CrossRefGoogle Scholar
  25. 25.
    Bloom SR, Polak JM, Pearse AGE: Vasoactive intestinal peptide and watery-diarrhoea syndrome, The Lancet II; 14–16, 1973CrossRefGoogle Scholar
  26. 26.
    Van der Haghan JJ, Signean J, Gepts W: New peptide in the central nervous system reacting with anti-gastrin antibodies. Nature 257: 604–605, 1975CrossRefGoogle Scholar
  27. 27.
    Dockray GJ: Immunochemical evidence of cholecystokinin-like peptides in brain. Nature 264: 568–560, 1976PubMedCrossRefGoogle Scholar
  28. 28.
    Polak JM, Buchan AMJ, Czykowska W, Solcia E, Bloom SR, Brown MI, Pearse AGE: Bombesin in the gut. In: Gut Hormones, edited by SR Bloom, Churchill Livingstone, Edinburgh, 1978, p. 540–542Google Scholar
  29. 29.
    Wharton J, Polak JM, Bloom SR, Ghatei MA, Solcia E, Brown MR, Pearse AGE: Bombesin-like immunoreactivity in the lung. Nature, in pressGoogle Scholar
  30. 30.
    Polak JM, Sullivan SN, Buchan AMJ, Bloom SR, Facer P, Hudson D, Pearse AGE: Endorphins. In: Gut Hormones, ed. SR Bloom, Churchill Livingstone, Edinburgh, 1978, p. 501Google Scholar
  31. 31.
    Feldberg W: Pharmacology of the central actions of endorphins. In: Gut Hormones, ed. SR Bloom, Churchill Livingstone, Edinburgh, 1978, p. 495Google Scholar
  32. 32.
    Richardson J: Pharmacologic studies of Hirschsprung’s disease on a murine model. J. Pediatr. Surg, 10: 875–884, 1975PubMedCrossRefGoogle Scholar
  33. 33.
    Baumgarten HG, Holstein AF, Stelzner F: Nervous elements in the human colon of Hirschsprung’s disease, Virchows Arch. Pathol. Anat. 358: 113–136, 1973CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. M. Polak
    • 1
  • S. R. Bloom
    • 1
  1. 1.Departments of Histochemistry and Medicine, The Royal Postgraduate Medical SchoolHammersmith HospitalLondonEngland

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