Effects of Bombesin and Calcium on Serum Gastrin Levels in Patients with Retained or Excluded Antral Mucosa
Serum gastrin levels and gastric acid output were determined under basal conditions, following i.v. infusion of bombesin (BBS) (15 ng kg-1 min-1 for 90 min), and following i.v, infusion of Ca++ (4 mg kg-1 hr-1 for 4 hours) in 28 postoperative peptic ulcer patients. In 5 patients antral mucosa was excluded with the duodenal stump (EAM) and in 8 patients it was retained on the lesser curve of the stomach (RAM). In 15 patients antrectomy was complete (control). Basal gastrin levels were higher in both EAM and RAM patients than in the control group. BBS infusion augmented gastrin levels in all incomplete antrectomy patients. Ca++ was less effective. No effect of BBS and Ca++ was apparent in the control group. In EAM patients basal and stimulated serum gastrin levels were significantly higher than in RAM patients.
KeywordsPeak Response Gastrin Level Gastric Antrum Serum Gastrin Level Antral Mucosa
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