Prostaglandins and Gastrointestinal Secretion and Motility
Prostaglandins (PGs) have been shown to be widely distributed in the gastrointestinal tract and implicated in the regulation of its secretory and motor activities. Despite their high biological activity and presence in the gastrointestinal system, their physiological role and the mechanisms by which they control digestive functions remain unknown. Interpretation of studies on the physiological significance of PGs is hampered by their rapid tissue catabolism which necessitates the administration of very high un-physiological doses of the substances, usually accompanied by various side-effects. Recently, several stable methyl analogs of PGE2 have been synthetized1 and proved to be highly effective in their action on various digestive functions, particularly in the inhibition of gastric secretion in animals and in man, in the prevention of experimental peptic ulcer formation in animals2,3 and in the healing of gastroduodenal ulcers in man4,5.
KeywordsArachidonic Acid Gastric Secretion Gastroduodenal Ulcer Gastric Mucosal Blood Flow Spike Potential
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