Polypeptides in Brain and Gut: Cholecystokinin-Like Peptides
The recognition that the same active polypeptide may occur in both brain and alimentary tract can be traced to the demonstration by von Euler and Gaddum of substance P in these two tissues1. Recent work suggests that there are a number of other peptides which may also be present in both brain and gut2. Thus substance P and neurotensin have been isolated from both tissues, somatostatin and enkephalin have been isolated from brain and identified in the gut by radioimmunoassay and immunocytochemistry, and vasoactive intestinal peptide has been isolated from gut and identified in brain by radioimmunoassay. In addition, there is now evidence, reviewed below, that factors resembling COOH-terminal fragments of the gut hormone cholecysto-kinin can be added to the list of brain-gut peptides3. The importance of cholecystokinin in the regulation of pancreatic secretion and gall bladder contraction has long been recognised, and in the present context it is interesting to note that exogenously administered cholecystokinin also has behavioural actions, notably influencing feeding and satiety4.
KeywordsAntral Mucosa Sodium Barbital Immunochemical Property Brain Component Gall Bladder Contraction
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