Polypeptides in Brain and Gut: Cholecystokinin-Like Peptides

  • G. J. Dockray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


The recognition that the same active polypeptide may occur in both brain and alimentary tract can be traced to the demonstration by von Euler and Gaddum of substance P in these two tissues1. Recent work suggests that there are a number of other peptides which may also be present in both brain and gut2. Thus substance P and neurotensin have been isolated from both tissues, somatostatin and enkephalin have been isolated from brain and identified in the gut by radioimmunoassay and immunocytochemistry, and vasoactive intestinal peptide has been isolated from gut and identified in brain by radioimmunoassay. In addition, there is now evidence, reviewed below, that factors resembling COOH-terminal fragments of the gut hormone cholecysto-kinin can be added to the list of brain-gut peptides3. The importance of cholecystokinin in the regulation of pancreatic secretion and gall bladder contraction has long been recognised, and in the present context it is interesting to note that exogenously administered cholecystokinin also has behavioural actions, notably influencing feeding and satiety4.


Antral Mucosa Sodium Barbital Immunochemical Property Brain Component Gall Bladder Contraction 
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  1. 1.
    Euler, US von, Gaddum JH: An unidentified depressor substance in certain tissue extracts. J. Physiol 72: 74–87, 1931Google Scholar
  2. 2.
    Pearse AGE: Peptides in brain and gut. Nature 262: 92–94, 1976CrossRefGoogle Scholar
  3. 3.
    Docray GJ: Immunochemical evidence of cholecystokinin-like peptides in brain. Nature 264: 568–570, 1976CrossRefGoogle Scholar
  4. 4.
    Sturdevant PAL, Goetz H: Cholecystokinin both stimulates and inhibits human food intake. Nature 261: 713–715, 1976PubMedCrossRefGoogle Scholar
  5. 5.
    Vanderhaeghen JJ, Signeau JC, Gepts W: New peptide in the vertebrate CNS reacting with antigastrin antibodies. Nature 257: 604–605, 1975PubMedCrossRefGoogle Scholar
  6. 6.
    Grossman MI: Gastrointestinal Hormones. In, Peptide hormones. Edited by JA Parsons, London, Macmillan Press, 1976, pp 106–116Google Scholar
  7. 7.
    Dockray GJ, Walsh JH: Amino-terminal gastrin fragment in serum of Zollinger-Ellison syndrome patients. Gastroenterology 68: 222–230, 1975PubMedGoogle Scholar
  8. 8.
    Dockray GJ, Taylor IL: Heptadecapeptide gastrin: measurement in blood by specific radioimmunoassay. Gastroenterology 71: 971–977, 1976PubMedGoogle Scholar
  9. 9.
    Polak JM, Szelke M, Bloom SR, et al: Use of synthetic fragments for specific immunostaining of CCK cells. Gastroenterology 72: A-12/822, 1977.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. J. Dockray
    • 1
  1. 1.Physiological LaboratoryUniversity of LiverpoolLiverpoolEngland

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