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The Inhibitory Action of Somatostatin on the Stomach

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 106))

Abstract

The finding of somatostatin-like immunoreactivity in the D-cells of the pancreas and in the lamina propria in the gastric wall1 has given evidence for a role of this peptide in the regulation of pancreatic and gastric functions. The recent discovery by Uvnäs-Wallensten et al. of somatostatin-like material in the gastric secretion2 and the description by Larsson et al. of a patient with a somatostatinoma3 give further support to the idea of a regulatory role of somatostatin in this area. In this presentation, the effects of somatostatin on the stomach will be reviewed and discussed.

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References

  1. Hokfeldt T, Efendic S, Hellstrom C, Johansson O, Luft R, Arimura A: Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special reference to the A1-cells of the pancreatic islets and to the hypothalamus area. Acta Endocrin. (Kbh). Suppl. 200, 5–41, 1975

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  2. Uvnäs-Wallensten K, Efendic S, Luft R: Vagal release of somatostatin into the antral lumen of cats. Acta Physiol. Scand. 99, 126–128, 1977

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  3. Larsson LI, Hirsch MA, Hoist JJ, Ingemansson S, Kühl C, Linkäer Jensen S, Lundquist G, Rehfeld JF, Schwarz TW: Pancreatic somatostatinoma. Clinical features and physiological implications. Lancet I, 666–668, 1977

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  4. Bloom SR, Mortimer CH, Thorner MO, Besser GM, Hall R, Gomez-Pan A, Roy VM, Russel RGG, Coy DH, Kastin AJ, Schally AV: Inhibition of gastrin and gastric acid secretion by growth hormone release-inhibiting hormone. Lancet II, 1106–1109, 1974

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  5. Vatn MH, Schrumpf E, Hanssen KF, Myren J: The effect of somatostatin on the pentagastrin-stimulated gastric secretion and on the release of gastrin in man. Scand. J. Gastroent. In press

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  6. Schlegel W, Raptis S, Dollinger HC, Pfeiffer EF: Inhibition of secretin-pancreozymin and gastrin release and their biological activities by somatostatin. pp. 361–377 in Bonfils et al. (eds). First International Symposium on Hormonal Receptors in Digestive Tract Physiology. Elsevier/North-Holland Biomedical Press, 1977

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  7. Konturek SJ, Tasler J, Ciesckowski M, Coy DH, Schally AV: Effect of growth hormone release-inhibiting hormone on gastric secretion, mucosal blood flow, and serum gastrin. Gastroenterology 70, 737–741, 1976

    PubMed  CAS  Google Scholar 

  8. Schrumpf E, Stadaas J, Hanssen KF: Somatostatin inhibits gastric motility in response to distention. Scand. J. Gastroent. 11, suppl. 38, 111, 1976

    Google Scholar 

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© 1978 Plenum Press, New York

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Schrumpf, E. (1978). The Inhibitory Action of Somatostatin on the Stomach. In: Grossman, M., Speranza, V., Basso, N., Lezoche, E. (eds) Gastrointestinal Hormones and Pathology of the Digestive System. Advances in Experimental Medicine and Biology, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7248-6_31

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  • DOI: https://doi.org/10.1007/978-1-4684-7248-6_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7250-9

  • Online ISBN: 978-1-4684-7248-6

  • eBook Packages: Springer Book Archive

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