The Inhibitory Action of Somatostatin on the Stomach

  • E. Schrumpf
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


The finding of somatostatin-like immunoreactivity in the D-cells of the pancreas and in the lamina propria in the gastric wall1 has given evidence for a role of this peptide in the regulation of pancreatic and gastric functions. The recent discovery by Uvnäs-Wallensten et al. of somatostatin-like material in the gastric secretion2 and the description by Larsson et al. of a patient with a somatostatinoma3 give further support to the idea of a regulatory role of somatostatin in this area. In this presentation, the effects of somatostatin on the stomach will be reviewed and discussed.


Gastric Motility Serum Gastrin Gastric Function Gastrin Release Pepsin Output 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Hokfeldt T, Efendic S, Hellstrom C, Johansson O, Luft R, Arimura A: Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special reference to the A1-cells of the pancreatic islets and to the hypothalamus area. Acta Endocrin. (Kbh). Suppl. 200, 5–41, 1975Google Scholar
  2. 2.
    Uvnäs-Wallensten K, Efendic S, Luft R: Vagal release of somatostatin into the antral lumen of cats. Acta Physiol. Scand. 99, 126–128, 1977PubMedCrossRefGoogle Scholar
  3. 3.
    Larsson LI, Hirsch MA, Hoist JJ, Ingemansson S, Kühl C, Linkäer Jensen S, Lundquist G, Rehfeld JF, Schwarz TW: Pancreatic somatostatinoma. Clinical features and physiological implications. Lancet I, 666–668, 1977CrossRefGoogle Scholar
  4. 4.
    Bloom SR, Mortimer CH, Thorner MO, Besser GM, Hall R, Gomez-Pan A, Roy VM, Russel RGG, Coy DH, Kastin AJ, Schally AV: Inhibition of gastrin and gastric acid secretion by growth hormone release-inhibiting hormone. Lancet II, 1106–1109, 1974Google Scholar
  5. 5.
    Vatn MH, Schrumpf E, Hanssen KF, Myren J: The effect of somatostatin on the pentagastrin-stimulated gastric secretion and on the release of gastrin in man. Scand. J. Gastroent. In pressGoogle Scholar
  6. 6.
    Schlegel W, Raptis S, Dollinger HC, Pfeiffer EF: Inhibition of secretin-pancreozymin and gastrin release and their biological activities by somatostatin. pp. 361–377 in Bonfils et al. (eds). First International Symposium on Hormonal Receptors in Digestive Tract Physiology. Elsevier/North-Holland Biomedical Press, 1977Google Scholar
  7. 7.
    Konturek SJ, Tasler J, Ciesckowski M, Coy DH, Schally AV: Effect of growth hormone release-inhibiting hormone on gastric secretion, mucosal blood flow, and serum gastrin. Gastroenterology 70, 737–741, 1976PubMedGoogle Scholar
  8. 8.
    Schrumpf E, Stadaas J, Hanssen KF: Somatostatin inhibits gastric motility in response to distention. Scand. J. Gastroent. 11, suppl. 38, 111, 1976Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • E. Schrumpf
    • 1
  1. 1.Research Laboratory of Gastroenterology, Dept. 9Ulleval University HospitalOsloNorway

Personalised recommendations