Somatostatin and Gastrointestinal Secretion and Motility

  • S. J. Konturek
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


Somatostatin, a hypothalamic growth hormone-release inhibiting hormone (GH-RIH), has been shown to suppress the secretion of many hypophyseal and extrahypophyseal hormones including gastrointestinal hormones such as gastrin, secretin, cholecystokinin, motilin, and vasoactive intestinal peptide. It was also found in laboratory animals and in man to be a potent inhibitor of gastrointestinal secretions induced both by exogenous and endogenous stimuli2–5. Recently, many analogs of somatostatin have been prepared in an attempt to increase biological activity and some of the analogs were found to preferentially suppress the secretion of some hormones6.


Gastric Secretion Pancreatic Secretion Myoelectric Activity Serum Gastrin Level Duodenal Ulcer Patient 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • S. J. Konturek
    • 1
  1. 1.Institute of PhysiologyMedical AcademyKrakowPoland

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