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Endocrine Cells of the Gastrointestinal Tract: General Aspects, Ultrastructure and Tumour Pathology

  • E. Solcia
  • C. Capella
  • R. Buffa
  • L. Usellini
  • P. Fontana
  • B. Frigerio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)

Abstract

The endocrine-like cells scattered among epithelial cells of the gastrointestinal mucosa differ in several aspects from the cells concentrated in endocrine glands. In the latter, abundant sinusoidal capillaries are in close contact with endocrine cells, thus ensuring prompt and massive release of secretory products into blood; close contacts with nerve endings are also found, particularly in the islets of the dog and cat. In the gut, various amounts of connective tissue are interposed between the basal membrane of the glands or villi and blood capillaries or nerve endings. In particular, no special or preferential relationship is found between endocrine-type cells and underlying blood vessels, although some long-distance correspondance between pyloric G cells and fenestrated capillaries seems to occur. The differences of innervation and blood supply may help explain the failure of gastric A cells to respond to stimuli known to be active on pancreatic A cells.1,2

Keywords

Endocrine Cell Nerve Ending Carcinoid Tumour Fenestrated Capillary Paracrine Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Lefebvre PJ, Luyckx AS: Factors controlling glucagon release by the isolated perfused dog stomach. EASD 13th Annual Meeting: Geneva, Switzerland, September 28–30, 1977Google Scholar
  2. 2.
    Solcia E, Capella C, Vassallo G, Buffa R: Endocrine cells of the gastric mucosa. Internat. Rev. Cytol. 42: 223–286, 1975CrossRefGoogle Scholar
  3. 3.
    Solcia E, Vassallo G, Sampietro R: Endocrine cells in the antropyloric mucosa of the stomach. Z Zellforsch. 81: 474–486, 1967PubMedCrossRefGoogle Scholar
  4. 4.
    Uvnas-Wallensten K: Secretion of gastrin into the antral lumen of cats and its regulation by intra-antral pH. Paper delivered at the “International Symposium on Gastrointestinal Hormones and Pathology of the Digestive System”. Rome, June 13–15, 1977Google Scholar
  5. 5.
    Vinik AI: Characterization of ‘gastrin’ released from mucosal surface of isolated human antra. Paper delivered at the “International Symposium on Gastrointestinal Hormones and Pathology of the Digestive System”. Rome, June 13–15, 1977Google Scholar
  6. 6.
    Feyrter F: Uber die peripheren endokrinen (parakrinen) Drüsen des Menschen. 2. Aufl. Wien-Düsseldorf: W Maudrich, 1953Google Scholar
  7. 7.
    Capella C, Hage E, Solcia E, Usellini L: Ultrastructural similarity of endocrine-like cells of the human lung and some related cells of the gut. Cell Tiss. Res. (in press, 1977)Google Scholar
  8. 8.
    Capella C, Solcia E, Frigerio B, Buffa R, Usellini L, Fontana P: The endocrine cells of the pancreas and related tumours. Virchows Arch. A Path. Anat. Histol. 373: 327–352, 1977CrossRefGoogle Scholar
  9. 9.
    Alumets J, Hakanson R, Ingemansson S, Sundler F: Substance P and 5HT in granules isolated from an intestinal argentaffin carcinoid. Histochemistry 52: 217–222, 1977PubMedCrossRefGoogle Scholar
  10. 10.
    Williams ED, Sandler M: The classification of carcinoid tumours. Lancet 1: 238–239, 1963PubMedCrossRefGoogle Scholar
  11. 11.
    Godwin JD: Carcinoid tumours. An analysis of 2837 cases. Cancer 36: 560–569, 1975PubMedCrossRefGoogle Scholar
  12. 12.
    Vorherr H, Massry SG, Fallet R, et al: Antidiuretic principle in tuberculous lung tissue of a patient with pulmonary tuberculosis and hyponatremia. Ann. Intern. Med. 72: 383–387, 1970PubMedGoogle Scholar
  13. 13.
    Gewirtz G, Yalow RS: Ectopic-ACTH production in carcinoma of the lung. J. Clin. Invest. 53: 1022–1032, 1974PubMedCrossRefGoogle Scholar
  14. 14.
    Yasuda N, Greer MA: Demonstration of corticotrophin-releasing activity in rat and human peripheral blood. Acta Endocr. 84: 1–10, 1977PubMedGoogle Scholar
  15. 15.
    Gleeson MH, Bloom SR, Polak JM, Henry K, Dowling RH: Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut 12: 773–782, 1971PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • E. Solcia
    • 1
  • C. Capella
    • 1
  • R. Buffa
    • 1
  • L. Usellini
    • 1
  • P. Fontana
    • 1
  • B. Frigerio
    • 1
  1. 1.Centro di Diagnostica IstopatologicaUniversita di Pavia a VareseVareseItaly

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