The Effect of Atropine on Secretin Release and Pancreatic Bicarbonate Secretion after Duodenal Acidification in Man
The aim of the present study was to investigate whether the release of secretin was under cholinergic control in man. This was postulated by O’Connor and co-workers3 but Ward and Bloom5 found vagotomy to be without effect on acid stimulated secretin release. Both groups employed radioimmunoassays for secretin determinations, but these investigations were carried out as unpaired comparisons. The present report gives the results of a randomized, paired investigation of immunoreactive secretin (IRS) release from the intestine after duodenal acidification with or without atropine infusion, together with the effect on duodenal aspirates.
KeywordsDuodenal Aspirate Bicarbonate Output Pancreatic Response Unpaired Comparison Cholinergic Control
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- 4.Tai HH, Lee KY and C ley WY. Does vagus effect endogenous release of secretin? International symposium on gastrointestinal hormones and pathology of the digestive system, Rome, 1977Google Scholar