The Effect of Atropine on Secretin Release and Pancreatic Bicarbonate Secretion after Duodenal Acidification in Man

  • L. E. Hanssen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


The aim of the present study was to investigate whether the release of secretin was under cholinergic control in man. This was postulated by O’Connor and co-workers3 but Ward and Bloom5 found vagotomy to be without effect on acid stimulated secretin release. Both groups employed radioimmunoassays for secretin determinations, but these investigations were carried out as unpaired comparisons. The present report gives the results of a randomized, paired investigation of immunoreactive secretin (IRS) release from the intestine after duodenal acidification with or without atropine infusion, together with the effect on duodenal aspirates.


Duodenal Aspirate Bicarbonate Output Pancreatic Response Unpaired Comparison Cholinergic Control 
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  1. 1.
    Hanssen LE, Hanssen KF and Myren J. Inhibition of secretin release and pancreatic bicarbonate secretion by somatostatin infusion in man. Scand. J. Gastroent. 1977, 12, 391–394PubMedCrossRefGoogle Scholar
  2. 2.
    Hanssen LE and Torjesen P. Radioimmunoassay of secretin in human plasma. Scand. J. Gastroent. 1977, 12, 481–488PubMedCrossRefGoogle Scholar
  3. 3.
    O’Connor FA, Buchanan KD, Connon JJ and Shahidullah M. Secretin and insulin: Response to intraduodenal acid. Diabetologia 1976, 12, 145–148PubMedCrossRefGoogle Scholar
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    Tai HH, Lee KY and C ley WY. Does vagus effect endogenous release of secretin? International symposium on gastrointestinal hormones and pathology of the digestive system, Rome, 1977Google Scholar
  5. 5.
    Ward AS and Bloom SR. Effect of vagotomy on secretin release in man. Gut 1975, 16, 951–956PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • L. E. Hanssen
    • 1
  1. 1.Research Laboratory of Gastroenterology, Dept. IX Internal MedicineUllevål HospitalOsloNorway

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