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Roles of the Vagus in Endogenous Release of Secretin and Exocrine Pancreatic Secretion in Dog

  • K. Y. Lee
  • W. Y. Chey
  • H. H. Tai
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)

Abstract

It has been well established that secretin1 is released from upper small intestinal mucosa in response to hydrogen ion delivered in the duodenum in man 2 and dog.3 As pH of the proximal duodenum decreased below 4.0 during the postprandial period, plasma secretin concentration increased significantly in man.4 We investigated a possible role of the vagus nerve in release of endogenous secretin in conscious dogs as well as anesthetized dogs.

Keywords

Pancreatic Fistula Pancreatic Secretion Exocrine Pancreatic Secretion Gastric Fistula Bicarbonate Secretion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bayliss WM, Starling EH: The mechanism of pancreatic secretion. J Physiol 28: 325–353, 1902PubMedGoogle Scholar
  2. 2.
    Rhodes RA, Tai HH, Chey WY: Observations on plasma secretin levels by radioimmunoassay in response to duodenal acidification and to a meat meal in humans. Amer J Digest Dis 21: 873–879, 1976CrossRefGoogle Scholar
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    Lee KY, Tai HH, Chey WY: Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. Am J Physiol 230: 784–789, 1976PubMedGoogle Scholar
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • K. Y. Lee
    • 1
  • W. Y. Chey
    • 1
  • H. H. Tai
    • 1
  1. 1.The Isaac Gordon Center for Digestive Diseases and the Department of MedicineGenesee Hospital and University of Rochester School of Medicine and DentistryRochesterUSA

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