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Gastric-Glucagon: Physiology and Pathology

  • P. J. Lefebvre
  • A. S. Luyckx
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)

Abstract

As recently reported by several groups of investigators1-3, the plasma of totally depancreatized dogs contains normal, or even increased, quantities of a material immunometrically indistinguishable from pancreatic glucagon by radioimmunoassays regarded as highly specific for this hormone. As emphasized by Sasaki et al.4, this post-pancreatectomy immunoreactivity cannot be attributed to a cross-reaction with high levels of “gut glucagon-like immunoreactivity”, a group of immunometrically dissimilar polypeptides whose level is not elevated after pancreatectomy5. However, glucagon cannot be detected in the blood of dogs that have undergone complete abdominal evisceration . Therefore, in the dog, the origin of extrapancreatic glucagon is likely to be an abdominal organ; other significant sources of glucagon, such as the salivary glands as reported in the rodents 7,8, are unlikely to exist.

Keywords

Glucagon Secretion Plasma Glucagon Glucagon Release Pancreatic Glucagon Arginine Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • P. J. Lefebvre
    • 1
  • A. S. Luyckx
    • 1
  1. 1.Division of Diabetes, Institute of MedicineUniversity of LiègeLiègeBelgium

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