Physiology and Pathophysiology of GIP
Two major physiological roles for GIP have been established. An enterogastrone-like action in dog, in which it has been shown that physiological doses of the hormone will inhibit gastric acid secretion stimulated by histamine, gastrin or insulin hypoglycaemia (1) and an insulinotropic action of the hormone in both dog and man (2,3). The important recent findings concerning the insulinotropic action of the hormone have led to the suggestion that the abbreviation GIP could also be interpreted as meaning glucose-dependent insulinotropic polypeptide (GIP) (4). These findings include the observations that glucose ingestion in man (5) and dog (2) will stimulate the release of immunoreactive GIP (IR-GIP) and that intravenous infusion of the hormone in man will potentiate glucose stimulated insulin release (6).
KeywordsOral Glucose Gastric Acid Secretion Maturity Onset Diabetes Insulinotropic Action Insulin Hypoglycaemia
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