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Pancreatic Polypeptide (PP)

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Gastrointestinal Hormones and Pathology of the Digestive System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 106))

Abstract

During purification of insulin a new hormone named pancreatic polypeptide (PP) was isolated independently by Kimmel (avian PP) and Chance2 (human, bovine, porcine, ovine and canine PP). PP is a 36 amino-acid straight chain polypeptide, with no apparent similarity in sequence with any known hormone. Only one or two aminoacids distinguish mammalian PP’s, whereas they have about 16 aminoacids in common with the avian counterpart.

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References

  1. Kimmel JR, Hayden LJ, Pollock HG: Isolation and characterization of a new pancreatic polypeptide hormone. J Biol Chem 250: 9369–9376, 1975

    PubMed  CAS  Google Scholar 

  2. Chance RE, Johnson MG, Koffenberger Jr JE, et al: Isolation and amino acid sequence of a new pancreatic polypeptide. Unpublished

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  3. Larsson LI, Sundler F, Håkanson R: Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells. Cell Tiss Res 156: 167–171, 1975

    Article  CAS  Google Scholar 

  4. Larsson LI, Sundler F, Håkanson R: Pancreatic polypeptide — a postulated new hormone: Identification of its cellular storage site by light and electron microscopic immunocytochemistry. Diabetologia 12: 211–226, 1976

    Article  PubMed  CAS  Google Scholar 

  5. Lin TM, Chance RE: Gastrointestinal actions of a new bovine pancreatic peptide (BPP). In Endocrinology of the gut. WY Chey and FP Brooks, editor. Thorofare, New Jersey. 1: 143–145, 1974

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  6. Lin TM, Evans DC, Chance RE, et al: Bovine pancreatic peptide: Action on gastric and pancreatic secretion in dogs. Am J Physiol 232 (3): E311–E315, 1977

    PubMed  CAS  Google Scholar 

  7. Floyd JC, Fajans SS, Pek S, Chance RE: A newly recognized pancreatic polypeptide; plasma levels in health and disease. Rec Progr Horm Res, 1977

    Google Scholar 

  8. Schwartz TW, Rehfeld, JF, Stadil F, et al: Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet I: 1102–1105, 1976

    Article  Google Scholar 

  9. Adrian TE, Bloom SR, Besterman HS, et al: Mechanism of pancreatic polypeptide release in man. Lancet I: 161–163, 1977

    Article  Google Scholar 

  10. Schwartz TW, Holst JJ, Lindkaer Jensen S, et al: XIth Acta Endocrinologia Congress, abstract, 1977

    Google Scholar 

  11. Schwartz TW, Rehfeld JF: Mechanism of pancreatic-polypeptide release. Lancet I: 697–698, 1977

    Article  Google Scholar 

  12. Schwartz TW, Stenquist S, Olbe L: Vagal influence on pancreatic polypeptide secretion. In “International Gut Hormone Symposium”, SR Bloom, ed, 1977

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Medical Biochemistry, University of Aarhus, Denmark

    T. W. Schwartz

Authors
  1. T. W. Schwartz
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Editor information

Editors and Affiliations

  1. Veterans Administration, Wadsworth Hospital Center, Los Angeles, California, USA

    Morton Grossman

  2. Institute of 3rd Surgical Pathology, University of Rome, Italy

    V. Speranza , N. Basso  & E. Lezoche ,  & 

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© 1978 Plenum Press, New York

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Schwartz, T.W. (1978). Pancreatic Polypeptide (PP). In: Grossman, M., Speranza, V., Basso, N., Lezoche, E. (eds) Gastrointestinal Hormones and Pathology of the Digestive System. Advances in Experimental Medicine and Biology, vol 106. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7248-6_20

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  • DOI: https://doi.org/10.1007/978-1-4684-7248-6_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7250-9

  • Online ISBN: 978-1-4684-7248-6

  • eBook Packages: Springer Book Archive

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