Hormonal Control of the Lower Esophageal Sphincter in Man and Dog: Reevaluation of the Present Manometric Method for Diagnosis of GE Reflux

  • Z. Itoh
  • R. Honda
  • K. Hiwatashi
  • I. Takahashi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


Previously, we reported that the contractile activity of the lower esophageal sphincter (LES) and stomach were coordinated during the interdigestive state1,2. Both the LES and stomach cycled between periods of strong contractions and longer periods of quiescence; these data were gathered by long-term measurements made by chronically implanted force transducers in conscious dogs. In the present study, we will report on the effect of gut hormones on LES interdigestive contractile activity in the dog and human.


Lower Esophageal Sphincter Contractile Activity Lower Esophageal Sphincter Pressure Paper Speed Gastric Body 
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • Z. Itoh
    • 1
  • R. Honda
    • 1
  • K. Hiwatashi
    • 1
  • I. Takahashi
    • 1
  1. 1.G. I. Laboratories, Department of SurgeryGunma University School of MedicineMaebashiJapan

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