Cimetidine Treatment in Zollinger-Ellison Syndrome

  • S. Bonfils
  • M. Mignon
  • G. Kloeti
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


Total gastrectomy is the accepted method of symptomatic treatment for the Zollinger-Ellison syndrome (ZES) but has disabling side-effects. However, treatment with H2-receptor antagonists has proved promising. The usefulness of this series of drug was first demonstrated with metiamide2,3 but despite the fact that only a small number of patients was studied, some practical and theoretical problems appeared: drug toxicity, assessment of efficacy of long term treatment, with variations consisting of an escape phenomenon or, conversely, prolonged secretory inhibition.1,2


Acid Secretion Total Gastrectomy Partial Gastrectomy Efficacy Criterion Acute Inhibition 
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  1. 1.
    Bonfils S, Bernier JJ, Mignon M, Hautefeuille R, Corbic M, Marteau J: Syndrome de Zollinger-Ellison traité médicalement par un inhibiteur des récepteurs H2 á l’histamine. Nouv Presse Med 1975, 4: 2377–2381PubMedGoogle Scholar
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    Bonfils S, Bernier JJ, Mignon M, Lambert R, Bernades P, L’Hirondel C, Accary JP, Kloeti G: Metiamide treatment in five patients with Zollinger-Ellison syndrome. Digestion 1977, 15: 43–52PubMedCrossRefGoogle Scholar
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    Bonfils S, Mignon M, Jian R, Kloeti G: Biological studies during long-term Cimetidine administration in the Zollinger-Ellison syndrome. In: Cimetidine. Edited by Burland WL, Simkins MA, Excerpta Medica, Amsterdam, Oxford. 1977, chapter 29, 311–321Google Scholar
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Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • S. Bonfils
    • 1
  • M. Mignon
  • G. Kloeti
  1. 1.Unité de Recherches de Gastroénterologie (INSERM U.10) et Service de Gastroénterologie BHospital BichatParis Cedex 18France

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