Cimetidine Treatment in Zollinger-Ellison Syndrome
Total gastrectomy is the accepted method of symptomatic treatment for the Zollinger-Ellison syndrome (ZES) but has disabling side-effects. However, treatment with H2-receptor antagonists has proved promising. The usefulness of this series of drug was first demonstrated with metiamide2,3 but despite the fact that only a small number of patients was studied, some practical and theoretical problems appeared: drug toxicity, assessment of efficacy of long term treatment, with variations consisting of an escape phenomenon or, conversely, prolonged secretory inhibition.1,2
KeywordsAcid Secretion Total Gastrectomy Partial Gastrectomy Efficacy Criterion Acute Inhibition
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