Role of the Small Bowel in Regulating Serum Gastrin and Gastric Inhibitory Polypeptide (GIP) Levels and Gastric Acid Secretion

  • H. D. Becker
  • N. J. Smith
  • H. W. Börger
  • A. Schafmayer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


An increase in gastric acid secretion after resection or bypass of the small bowel has been described by several authors in man and dogs1,2,3. Furthermore, a high incidence of peptic ulcer disease has been observed in patients with small bowel resection4,5. The mechanism which induces gastric hypersecretion after exclusion of large parts of the small bowel from food passage is still poorly understood. Several authors have described hypergastrinemia after small bowel exclusion or bypass, which may be caused by either a decrease in catabolism or a diminished release of inhibitors from the small intestine6,7,8. One of the physiologically important inhibitors of gastric acid secretion may be the gastric inhibitory polypeptide (GIP) which is released from the duodenum and jejunum after food intake and shows besides its insulinotropic effect a strong inhibition of stimulated acid secretion in dogs9.


Small Bowel Acid Secretion Gastric Acid Secretion Short Bowel Syndrome Serum Gastrin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Osborne MP, Frederich PL, Sizer JS, et al: Mechanism of gastric hypersecretion following massive small bowel resection. Ann. Surg. 164; 622, 1966PubMedCrossRefGoogle Scholar
  2. 2.
    Wise L, Vanghan R, Stein TH: Studies on the effect of small bowel bypass for massive obesity on gastric secretory function. Ann. Surg. 183; 259, 1976PubMedCrossRefGoogle Scholar
  3. 3.
    Buchwald H, Coyle JJ, Varco RL: Effect of small bowel bypass on gastric secretory function: Post-intestinal exclusion hypersecretion. Surgery 75; 821, 1974PubMedGoogle Scholar
  4. 4.
    Frederich PL, Sizer JS, Osborne MP: Relation of massive small bowel resection to gastric secretion. N. Engl. J. Med. 272; 509, 1965CrossRefGoogle Scholar
  5. 5.
    Winawer SJ, Broitman SA, Osborne MP, Zamchetzn: Successful management of massive small bowel resection based on assessment of absorption defects and nutritional needs. N. Engl. J. Med. 274; 72, 1966PubMedCrossRefGoogle Scholar
  6. 6.
    Straus E, Gerson CD, Yalow RS: Hypersecretion of gastrin associated with the short bowel syndrome. Gastroenterology 66; 175, 1974PubMedGoogle Scholar
  7. 7.
    Becker HD, Reeder DD, Thompson JC: Extraction of circulating endogenous gastrin by the small bowel. Gastroenterology 65; 903, 1973PubMedGoogle Scholar
  8. 8.
    Straus E, Yalow RS: Differential diagnosis of hypergastrinemia. In: Thompson JC: Gastrointestinal hormones. University of Texas Press, Austin, 1975Google Scholar
  9. 9.
    Brown JC, Dryburgh JR, Moccia P, Pederson RA: The current status of GIP. In: Thompson JC: Gastrointestinal hormones. University of Texas Press, Austin, 1975Google Scholar
  10. 10.
    Mayer G, Arnold R, Feurle G, Fuchs K, Ketterer H, Track NS, Creutzfeldt W: Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients. Scand. J. Gastroenterol. 9; 703, 1974PubMedGoogle Scholar
  11. 11.
    Kuzio M, Dryburgh JR, Malloy KM, Brown JC: Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology 66; 357, 1974PubMedGoogle Scholar
  12. 12.
    Solhaug JH, Schrumpf E: Effect of small bowel bypass on serum gastrin levels and gastric acid secretion in man. Scand. J. Gastroent. 11; 329, 1976PubMedGoogle Scholar
  13. 13.
    Coyle JJ, Varco RL, Buchwald H: Gastric secretion and serum gastrin in human small bowel bypass. Arch. Surg. 110; 1036, 1975PubMedCrossRefGoogle Scholar
  14. 14.
    Wickbom G, Landor JH, Bushkin FL, Mc Guigan JE: Changes in canine gastric acid output and serum gastrin levels following massive small intestinal resection. Gastroenterology 69; 448, 1975PubMedGoogle Scholar
  15. 15.
    Junghanns K, Kaess H, Dörner M, Encke A: The influence of resection of the small intestine on gastrin levels. SGO 140; 27, 1975PubMedGoogle Scholar
  16. 16.
    Lennon J, Lidgard GP, Tarry SH, Sircus W: Gastrin response to a standard meal after jejuno-ileal bypass in morbid obese patients. Gut 16; 407, 1975PubMedGoogle Scholar
  17. 17.
    Strunz U, Grossman MI: Removal of gastrin by various organs. Cure Symposium: Hormones and Peptic Ulcer. Los Angeles, October 1976.Google Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • H. D. Becker
    • 1
  • N. J. Smith
    • 1
  • H. W. Börger
    • 1
  • A. Schafmayer
    • 1
  1. 1.Department of SurgeryUniversity of GoettingenGermany

Personalised recommendations