Different Forms of Gastrin in Peptic Ulcer
The role of gastrin in the pathogenesis of peptic ulcer disease has received considerable attention in recent years1. It is now known that patients with duodenal ulcer are more sensitive to penta-gastrin than normal subjects and have higher than normal postprandial serum gastrin concentrations, possibly due to impairment of inhibition of gastrin release by acid1. However, the significance of these observations remains difficult to interpret because gastrin is known to circulate in several different forms which differ in their biological activity. The main forms isolated from gastrinomas and antral mucosa are big gastrin, or G34, and little gastrin, or G172. Other forms have also been identified but these either circulate in low concentrations or are not biologically active; they include mini-gastrin (G14), an NH2-terminal fragment of G17, and two forms which are probably larger than G34 (big, big gastrin and Rehfeld’s component I)2. In man and dog, Walsh has shown that the circulating concentrations of G34 required to stimulate half maximal rates of acid secretion are five-six times greater than those of Gl7, and that the metabolic clearance rates of G34 are about one fifth those of G173,4.
KeywordsDuodenal Ulcer Gastric Ulcer Standard Meal Duodenal Ulcer Patient Metabolic Clearance Rate
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- 2.Gregory RA: The gastrointestinal hormones: a review of recent advances. J Physiol 24: 1–32, 1974Google Scholar
- 3.Walsh JH, Debas HT, Grossman MI: Pure human big gastrin: immunochemical properties, half-life and acid stimulating activity in dogs. Gastroenterology 54: 477–485, 1974Google Scholar
- 5.Yalow RS: Heterogeneity of peptide hormones with relation to gastrin. In, Gastrointestinal hormones, edited by JC Thompson, Austin, Texas. University of Texas Press, 1975, pp 25–41Google Scholar