Different Forms of Gastrin in Peptic Ulcer

  • G. J. Dockray
  • I. L. Taylor
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 106)


The role of gastrin in the pathogenesis of peptic ulcer disease has received considerable attention in recent years1. It is now known that patients with duodenal ulcer are more sensitive to penta-gastrin than normal subjects and have higher than normal postprandial serum gastrin concentrations, possibly due to impairment of inhibition of gastrin release by acid1. However, the significance of these observations remains difficult to interpret because gastrin is known to circulate in several different forms which differ in their biological activity. The main forms isolated from gastrinomas and antral mucosa are big gastrin, or G34, and little gastrin, or G172. Other forms have also been identified but these either circulate in low concentrations or are not biologically active; they include mini-gastrin (G14), an NH2-terminal fragment of G17, and two forms which are probably larger than G34 (big, big gastrin and Rehfeld’s component I)2. In man and dog, Walsh has shown that the circulating concentrations of G34 required to stimulate half maximal rates of acid secretion are five-six times greater than those of Gl7, and that the metabolic clearance rates of G34 are about one fifth those of G173,4.


Duodenal Ulcer Gastric Ulcer Standard Meal Duodenal Ulcer Patient Metabolic Clearance Rate 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Walsh JH, Grossman MI: Gastrin. New Engl J Med 292: 1324–1332, 1975CrossRefGoogle Scholar
  2. 2.
    Gregory RA: The gastrointestinal hormones: a review of recent advances. J Physiol 24: 1–32, 1974Google Scholar
  3. 3.
    Walsh JH, Debas HT, Grossman MI: Pure human big gastrin: immunochemical properties, half-life and acid stimulating activity in dogs. Gastroenterology 54: 477–485, 1974Google Scholar
  4. 4.
    Walsh JH, Isenberg JI, Arnfield J et al: Clearance and acid-stimulating action of human big and little gastrin in duodenal ulcer subjects. J Clin Invest 57: 1125–1131, 1976PubMedCrossRefGoogle Scholar
  5. 5.
    Yalow RS: Heterogeneity of peptide hormones with relation to gastrin. In, Gastrointestinal hormones, edited by JC Thompson, Austin, Texas. University of Texas Press, 1975, pp 25–41Google Scholar
  6. 6.
    Dockray GJ, Taylor IL: Heptadecapeptide gastrin: measurement in blood by specific radioimmunoassay. Gastroenterology 71: 971–977, 1976PubMedGoogle Scholar
  7. 7.
    Taylor IL, Dockray GJ: Little gastrin response to a meal; a comparison between patients with duodenal ulceration and normal subjects. Gut 17: 393, 1976PubMedGoogle Scholar
  8. 8.
    Isenberg JI, Grossman MI, Maxwell V et al: Increased sensitivity to stimulation of acid secretion by pentagastrin in duodenal ulcer. J Clin Invest 55: 330–337, 1975PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • G. J. Dockray
    • 1
  • I. L. Taylor
    • 1
  1. 1.Physiological LaboratoryUniversity of LiverpoolLiverpoolEngland

Personalised recommendations