Analytical Requirements of Automated Pharmaceutical Analysis
The automation of pharmaceutical analysis was seriously undertaken in 1957 when a system and methodology for the automated analysis of streptomycin and penicillin were presented at the 132nd Annual Meeting of the American Chemical Society in New York City. Since then a wealth of literature in the form of individual papers and monographs of conferences at the New York Academy of Sciences and elsewhere have testified both to the need for and concern of the scientific community to provide better analytical procedures and means to the control of and manufacture of pharmaceutical products. In the past fourteen years, changes for the better in the analysis of pharmaceutical products have been enacted by the U. S. Pharmacopoeia, i.e., single tablet assays. In addition, the pharmaceutical drug manufacturers have developed and improved upon analytical procedures and adapted many of these for increased productivity and quality control in their laboratories. Several papers in the past have indicated that these newer concepts can provide information on drugs and their effects upon living matters, as well as to elicit information on the mechanisms by which they exert their action in the animal body and on the normal metabolic processes of microorganisms and parasites. The above will be discussed and reviewed.