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Brain and Myelin Sterols Studied Using Specific Inhibitors of Sterol Synthesis

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Chemistry and Brain Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 13))

Abstract

Sterols are major components of brain cellular and subcellular membranes and they are represented almost exclusively in mature mammalian brain by non-esterified cholesterol. However, during brain maturation and myelin deposition, stages of development characterized by a high rate of cholesterol biosynthesis, considerable amounts of desmosterol, a sterol precursor of cholesterol, are present in the brain of several mammalian species, i ncIudi ng man (1).

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References

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Author information

Authors and Affiliations

  1. Institute of Pharmacology, University of Milan, 20129, Milan, Italy

    R. Fumagalli

Authors
  1. R. Fumagalli
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology and Pharmacognosy, University of Milan, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

  2. Department of Biochemistry, Charing Cross Hospital Medical School, University of London, UK

    Alan N. Davison (Professor of Biochemistry) (Professor of Biochemistry)

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© 1971 Plenum Press, New York

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Fumagalli, R. (1971). Brain and Myelin Sterols Studied Using Specific Inhibitors of Sterol Synthesis. In: Paoletti, R., Davison, A.N. (eds) Chemistry and Brain Development. Advances in Experimental Medicine and Biology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7236-3_5

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  • DOI: https://doi.org/10.1007/978-1-4684-7236-3_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7238-7

  • Online ISBN: 978-1-4684-7236-3

  • eBook Packages: Springer Book Archive

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