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General Features of the Synaptic Organization in the Central Nervous System

  • Constantino Sotelo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 13)

Abstract

Nervous tissue is composed of two types of cells, neurons and neuroglia cells, derived from the primitive neuroepithelium. Based on its epithelial, origin and on its morphological types of connections, the nervous tissue has been compared to an epithelium (1), where the cells are packed close together, leaving a very small extracellular space (150 to 200 A wide) between each other, and isolated from the blood vessels by a basal membrane. As will be detailed further on, the junctional complexes described by Farquhar and Palade (2) between epithelial cells are present, with additional characteristics, in the nervous tissue.

Keywords

Synaptic Vesicle Active Zone Cerebellar Cortex Axon Terminal Synaptic Organization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Palay, S.L. in The Neurosciences (Eds. G.C. Quarton, T. Melnechuk, P.O. Schmitt), p. 24, Rockefeller Univ. Press. (1967)Google Scholar
  2. 2.
    Farquhar, M.G., and Palade, G.E. J. Cell Biol. 17:575 (1965)Google Scholar
  3. 5.
    Ramon y Cajal, S. Trab. Lab. Invest, biol. Univ. Madr. 29:1 (1954)Google Scholar
  4. 4.
    Sherrington, L.S. in A Text-Book of Physiology, vol. 5 (Ed. M. Foster) Macmillan, (1897)Google Scholar
  5. 5.
    Ramon y Cajal, S. Rev. Trim. Microgr. 1:1 (1897)Google Scholar
  6. 6.
    Furshpan, E.J., and Potter, D.B. J. Physiol. 145:289 (1959)PubMedGoogle Scholar
  7. 7.
    Palade, G.E., and Palay, S.L. Anat. Rec. 118:555 (1954)Google Scholar
  8. 8.
    Be Robertis, E., and Bennett, H.S. Federation Proc. 13: 55 (1954)Google Scholar
  9. 9.
    Gray, E.G., and Guillery, R.W. Intern. Rev. Cytol. 19: 111 (1966)CrossRefGoogle Scholar
  10. 10.
    Peters, A., Palay, S.L. and Webster, H. de F. The Fine Structure of the Nervous System — The Cells and their Processes. Hoeber/Harper and Row (1970)Google Scholar
  11. 11.
    Nakajima, Y., Pappas, G.D., and Bennett, M.V.L. Am. J. Anat. 116:471 (1965).PubMedCrossRefGoogle Scholar
  12. 12.
    Palay, S.L. Exptl. Cell Res. Suppl. 5:275 (1958)Google Scholar
  13. 13.
    Couteaux, R. Actualités Neurophysiol. 3e série:145 (1961)Google Scholar
  14. 14.
    Pick, J., Gerdin, C., and Delemos, C. Z. Zeilforsch. 62: 402 (1964)CrossRefGoogle Scholar
  15. 15.
    Glees, P., and Sheppard, B.L. Z. Zeilforsch. 62:556(1964)CrossRefGoogle Scholar
  16. 16.
    Gray, E.G. J. Anat. 93:420 (1959)PubMedGoogle Scholar
  17. 17.
    Bloom, F.E., and Aghajanian, G.K. J. Ultrastruct. Res. 22:361 (1968)PubMedCrossRefGoogle Scholar
  18. 18.
    Aghajanian, G.K., and Bloom, F.E. Brain Res. 6:716 (1967)PubMedCrossRefGoogle Scholar
  19. 19.
    Pfenninger, K., Sandri, C., Akert, K., and Eugster, C.H. Brain Res. 12:10 (1969)PubMedCrossRefGoogle Scholar
  20. 20.
    Akert, K., Moor, H., Pfenninger, K., and Sandri, C. Prog. Brain Res. 31:223 (1969)PubMedCrossRefGoogle Scholar
  21. 21.
    Akert, K., Moor, H., and Pfenninger, K. in First Int. Symp. on Cell Biol. and Cytopharmacol. Venice 1969, Raven Press (in press)Google Scholar
  22. 22.
    Gray, E.G. in Electron Microscopy in Anatomy (Eds J.D. Boyd, P.R. Johnson, and J.E. Lever) p. 54, Arnold, (1961)Google Scholar
  23. 23.
    Gray, E.G. J. Anat. 251:346 (1961)Google Scholar
  24. 24.
    Colonnier, M. Brain Res. 2:268 (1968)CrossRefGoogle Scholar
  25. 25.
    Robertson, J.D. Neurosciences Res. Prog. Bull. 3(No.4): 17(1965)Google Scholar
  26. 26.
    Pappas, G.B., and Purpura, B.P. Nature 210:1591 (1966)CrossRefGoogle Scholar
  27. 27.
    Rambourg, A., and Leblond, C.P. J. Cell Biol. 52:27 (1967)CrossRefGoogle Scholar
  28. 28.
    Gray, E.G., and Whittaker, V.P. J. Anat. 96:79 (1962)PubMedGoogle Scholar
  29. 29.
    Brightman, M.W. Prog. Brain Res. 29:19 (1967)CrossRefGoogle Scholar
  30. 30.
    Be Robertis, E. in Cellular Dynamics of the Neuron (Ed. S.H. Barondes) p. 191, Academic Press (1969)Google Scholar
  31. 31.
    Sotelo, C. unpublished observations.Google Scholar
  32. 32.
    Palay, S.L. in Cytology of the Nervous Tissue; Proceedings of the Anatomical Society of Great Britain and Ireland, p. 82, Taylor and Francis, (1961)Google Scholar
  33. 33.
    Fatt, P., and Katz, B. J. Physiol. 117:109 (1952)PubMedGoogle Scholar
  34. 34.
    Bel Castillo, J., and Katz, B. Prog. Biophys. Biochem. Chem. 6:121 (1956)Google Scholar
  35. 35.
    Akert, K., and Sandri, C. Brain Res. 7:286 (1968)PubMedCrossRefGoogle Scholar
  36. 36.
    De Robertis, E., Rodriguez de Lores Arnaiz, G., Salganicoff, L., Pellegrino de Iraldi, A., and Zieher, L.M. J. Neurochem. 10:225 (1963)CrossRefGoogle Scholar
  37. 37.
    Whittaker, V.P., Michaelson, I.A., and Kirkland, R.J.A. Biochem. Pharmacol. 12:300 (1963)PubMedCrossRefGoogle Scholar
  38. 38.
    Israël, M., and Gautron, J. in Cellular Dynamics of the Neuron (Ed. S.H. Barondes) p. 137, Academic Press (1969)Google Scholar
  39. 39.
    De Robertis, E. Intern. Rev. Cytol. 8:61 (1959)CrossRefGoogle Scholar
  40. 40.
    Marchbanks, R.M. in Cellular Dynamics of the Neuron (Ed. S.H. Barondes) p. 115, Academic Press (1969)Google Scholar
  41. 41.
    Hubbard, J.I., and Kwanbunbumpen, S. J. Physiol. 194: 407 (1968)PubMedGoogle Scholar
  42. 42.
    Clark, A.W., Mauro, A., Longenecker, H.E., and Hurlbut, W. Nature 225:705 (1970)CrossRefGoogle Scholar
  43. 43.
    Walberg, P. J. Ultrastruct. Res. 12:237 (1965)Google Scholar
  44. 44.
    Uchizono, K. Nature 207:642 (1965)PubMedCrossRefGoogle Scholar
  45. 45.
    Sotelo, C., and Taxi. J. unpublished observations.Google Scholar
  46. 46.
    Bodian, D. Science 151:1093 (1966)PubMedCrossRefGoogle Scholar
  47. 47.
    Lenn, N.J., and Reese, T.S. Am. J. Anat. 118:375 (1966)PubMedCrossRefGoogle Scholar
  48. 48.
    Larramendi, L.M.H., Pickenscher, L., and Lemkey-Johnston, N. Science 156:967 (1967)PubMedCrossRefGoogle Scholar
  49. 49.
    Bodian, D. Bull. Johns Hopkins Hosp. 118:282 (1966)Google Scholar
  50. 50.
    Kruger, L., and Maxwell, D.S. Am. J. Anat. 119:479 (1966).PubMedCrossRefGoogle Scholar
  51. 51.
    Van Orden, L.S., III, Bloom, P.E., Barrnett, R.J., and Giarman, N.J. J. Pharmacol. Exptl. Therap. 154:185 (1966)Google Scholar
  52. 52.
    Hökfelt, T. Z. Zellforsch. 79:110 (1967)PubMedCrossRefGoogle Scholar
  53. 53.
    Hskfelt, T. Z. Zellforsch. 21:1 (1968)CrossRefGoogle Scholar
  54. 54.
    Palay, S.L. Anat. Record 158:417 (1960)CrossRefGoogle Scholar
  55. 55.
    Richards, J.G., and Tranzer, J.P. Brain Res. 17:465 (1970)CrossRefGoogle Scholar
  56. 56.
    Sotelo, C. in preparation.Google Scholar
  57. 57.
    Droz, B., and Barondes, S.H. Science 165:1131 (1969)PubMedCrossRefGoogle Scholar
  58. 58.
    Sotelo, C., and Palay, S.L. Lab. Invest. (in press).Google Scholar
  59. 59.
    Westrum, L.E.. and Blacks tad, T.W. J. Comp. Neurol. 119:281 (1962)PubMedCrossRefGoogle Scholar
  60. 60.
    Gray, E.G., and Guillery, R.W. J. Anat. 21:389 (1963)Google Scholar
  61. 61.
    Palay, S.L., Sotelo, C., Peters, A., and Orkand, P.M. J. Cell Biol. 38:193 (1968)PubMedCrossRefGoogle Scholar
  62. 62.
    Peters, A., Proskauer, C.C., and Kaiserman-Abramof, I.R. J. Cell Biol. 39:604 (1968)PubMedCrossRefGoogle Scholar
  63. 63.
    Herndon, R.M. J. Cell Biol. 20:338 (1964)PubMedCrossRefGoogle Scholar
  64. 64.
    Schultz, R.L., and Karlsson, U. J. Ultrastructj Res. 14:268 (1966)CrossRefGoogle Scholar
  65. 65.
    Scheibel, M.E., and Scheibel, A.B. in Communications in Behavioral Biology, Part A, 1:231 (1968)Google Scholar
  66. 66.
    Taxi, J. Compt. Rend. Acad. Sci. 252:174 (1961)Google Scholar
  67. 67.
    Sotelo, C. Exptl. Brain Res. 6:294 (1968)CrossRefGoogle Scholar
  68. 68.
    Gray, E.G. J. Anat. 21:101 (1963)Google Scholar
  69. 69.
    Akert, K., Pfenninger, K., and Sandri, C. Z. Zeilforsch. 81:537 (1967)CrossRefGoogle Scholar
  70. 70.
    Milhaud, M., and Pappas, G.B. J. Cell Biol. 20:437 (1966)CrossRefGoogle Scholar
  71. 71.
    Sotelo, C. unpublished observations.Google Scholar
  72. 72.
    Lund, R.D. J. Comp. Neurol. 135:179 (1969)CrossRefGoogle Scholar
  73. 73.
    Sotelo, C., and Palay, S.L. Brain Res. 18:93 (1970)PubMedCrossRefGoogle Scholar
  74. 74.
    Robertson, J.D., Bodenheimer, T.S., and Stage, D.E. J. Cell Biol. 12:159 (1963)CrossRefGoogle Scholar
  75. 75.
    Palay, S.L. in Brain Function, Vol. 2, RM and Brain Function; Memory and Learning (Ed. M.A.B. Brazier) p. 69, Univ. of Calif. Press (1964)Google Scholar
  76. 76.
    Hamori, J., and Szentagothai, J. Acta Biol. Hung, 15: 465 (1965)Google Scholar
  77. 77.
    Furukawa, T., and Furshpan, E.J. J. Neurophysiol. 26: 140 (1963)PubMedGoogle Scholar
  78. 78.
    Ecoles, J.C., Llinas, R., and Sasaki, K. Ezptl. Brain Res. 1:1 (1966)CrossRefGoogle Scholar
  79. 79.
    Caravita, S. personal communication.Google Scholar
  80. 80.
    Gray, E.G. Nature 195:82 (1962)CrossRefGoogle Scholar
  81. 81.
    Ramon y Cajal, S. Histologie du Système Nerveux de l’Homme et des Vertébrés. Vols. I and II. Reprinted by C.S.I. C. (Madrid) (1952)Google Scholar
  82. 82.
    Bowling, J.E., and Boycott, B.B. Proc. Roy. Soc. Série B 166:80 (1966)CrossRefGoogle Scholar
  83. 83.
    Raviola, G., and Raviola, E. Am. J. Anat. 120:405 (1967)Google Scholar
  84. 84.
    Hirata, Y. Arch. Histol. Jap. 24:293 (1964)PubMedCrossRefGoogle Scholar
  85. 85.
    Andres, K.H. Z. Zeilforsch. 65:530 (1965)CrossRefGoogle Scholar
  86. 86.
    Hall, W., Shepherd, G.M., Reese, T.S., and Brightman, M.W. Exptl. Neurol. 14:44 (1966)CrossRefGoogle Scholar
  87. 87.
    Price, J.L. Brain Hes. 2:483 (1968)CrossRefGoogle Scholar
  88. 88.
    Hirata, Y. Arch. Histol. Jap. 22:373 (1966)Google Scholar
  89. 89.
    Guillery, R.W. Z. Zellforsch. 96:1 (1969)PubMedCrossRefGoogle Scholar
  90. 90.
    Ralston, H.J. III, and Herman, M.M. Brain Res. 14:77 (1969).PubMedCrossRefGoogle Scholar
  91. 91.
    Sétalo, G., and Székely, G. Exptl. Brain Res. 4:237 (1967)CrossRefGoogle Scholar
  92. 92.
    Taue, L., and Gerschenfeld, H.M. Mature 192:566 (1961)CrossRefGoogle Scholar
  93. 93.
    Ecoles, J.C. The physiology of Synapses, Springer Verlag (1964)CrossRefGoogle Scholar
  94. 94.
    Ecoles, J.C., Ito, M., and Szentàgothai, J. The Cerebellum as a Neuronal Machine, Springer Verlag (1967)Google Scholar
  95. 95.
    Sotelo, C. in Neurobiology of Cerebellar Evolution and Development, (Ed. R. Llinas), p. 327, Am. Med. Association (1969)Google Scholar
  96. 96.
    Larramendi, L.M.H., and Victor, T. Brain Res. 5:15 (1967)PubMedCrossRefGoogle Scholar
  97. 97.
    Mugnaini, E. Brain Res. 12:169 (1970)CrossRefGoogle Scholar
  98. 98.
    Uchizono, K. Exptl. Brain Res. 4:97 (1967)CrossRefGoogle Scholar
  99. 99.
    Bodian, D. J.Gomp.Neurol. 153:113 (1968)CrossRefGoogle Scholar
  100. 100.
    Walberg, P. Exptl. Brain Res. 2:107 (1966)CrossRefGoogle Scholar
  101. 101.
    Bennett, M.V.L., Nakajima, Y., and Pappas, G.D. J. Neurophysiol. 30:161 (1967)PubMedGoogle Scholar
  102. 102.
    Bennett, M.V.L., Pappas, G.D., Aljure, E., and Nakajima, T. J. Neurophysiol. 30:180 (1967)PubMedGoogle Scholar
  103. 103.
    Bennett, M.V.L., Nakajima, Y.. and Pappas, G.D. J. Neurophysiol. 30:209 (1967)PubMedGoogle Scholar
  104. 104.
    Bennett, M.V.L., Pappas, G.D., Giménez, M., and Nakajima, Y. J. Neurophysiol. 30:236 (1967)PubMedGoogle Scholar
  105. 105.
    Pappas, G.D., Asada, Y., and Bennett, M.V.L. Anat. Record 157:297 (1967)Google Scholar
  106. 106.
    Karnovsky, M.J. J. Cell Biol. 35:213 (1967)PubMedCrossRefGoogle Scholar
  107. 107.
    Revel, J.P., and Earnovsky, M.J. J. Cell Biol. 33:67Google Scholar
  108. 108.
    Brightman, M.W., and Reese, T.S. J. Cell Biol. 40:648 (1969)PubMedCrossRefGoogle Scholar
  109. 109.
    Robertson, J.D. J. Cell Biol. 19:201 (1963)PubMedCrossRefGoogle Scholar
  110. 110.
    Eaiserman-Abramof, I.R., and Palay, S.L. in Neurobiology of Cerebellar Evolution and Development (Ed. R. Llinas) p. 171, Am. Med. Association (1969)Google Scholar
  111. 111.
    Charlton, B.T., and Gray, E.G. J. Cell Sci. 1:67 (1966)PubMedGoogle Scholar
  112. 112.
    Sotelo, C., and Taxi, J. Brain Res. 17:137 (1970)PubMedCrossRefGoogle Scholar
  113. 113.
    Hinojosa, R., and Robertson, J.D. J. Cell Biol. 34:421 (1967)PubMedCrossRefGoogle Scholar
  114. 114.
    Grinnell, A.D. J. Physiol. 182:612 (1966)PubMedGoogle Scholar
  115. 115.
    Hinriohsen, C.F.L., and Larramendi, L.M.H. Brain Res. 7:296 (1968)CrossRefGoogle Scholar
  116. 116.
    Martin, A.R., and Pilar, G. J. Physiol. 168:443 (1963)PubMedGoogle Scholar
  117. 117.
    Takahashi, K., and Hama, K. Z. Zeilforsch. 61:174 (1965)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Constantino Sotelo
    • 1
    • 2
  1. 1.Laboratoire de Biologie AnimaleFaculté des Sciences Paris 5France
  2. 2.Laboratoire d’Histologie Normale et Pathologique du Système Nerveux de L’I.N.S.E.R.M.Hôpital Port-RoyalParis 14France

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