Skip to main content
SpringerLink
Log in
Book cover

Chemistry and Brain Development pp 15–29Cite as

Role of Nucleic Acids in Brain Development

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 13))

Abstract

The aim of this article is to provide a survey of the experimental findings which relate to the role of nucleic acids in brain development, with no pretence at a complete coverage, but also to present some of the evidence obtained with comparable systems wherever this may by useful to illustrate a concept or a possible mechanism. The metabolic behaviour of nucleic acids is at the core of the theory which attempts to explain development in terms of gene action and of its control (repression and derepression) in strictly ordered patterns in space and time. To provide even a cursory appreciation of the complexities which this mechanism is called upon to explain, we will start with a brief description of the main categories of biological events which occur during the growth of the nervous system. This will be also useful in discussing the limits of this theory, at least in its current formulation, and the possible other factors which may contribute to the molding of growing nerve tissues.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Altman, J. in Handbook of Neurochem., vol. 2, p. 137 (Ed. A. Lajtha) Plenum Press (1969).

    Google Scholar 

  2. Eceles, J. C. Proc. Natl. Acad. Sci. US 66:294 (1970).

    Article  Google Scholar 

  3. Caley, D. W. and Maxwell, D.S. J. Comp. Neurol. 133:17 (1968).

    Article  CAS  Google Scholar 

  4. Wechsler, A. and Keller, K. Progr.Brain.Res.26:93 (1967

    Article  CAS  Google Scholar 

  5. Mori, S., and Leblond, O.P. J. Comp.Neurol.139:1 (1970).

    Article  PubMed  CAS  Google Scholar 

  6. McIlwain, H. in Biochemistry and the Central Nervous System, 3rd Ed., Churchill (1966).

    Google Scholar 

  7. Schonbach, J. et al. J. Comp. Neurol. 134:21 (1968).

    Article  PubMed  CAS  Google Scholar 

  8. Sperry, R.W. Proc.Natl.Acad.Sci.US 50:703 (1963).

    Article  CAS  Google Scholar 

  9. Hess, A. Biol. Rev. 32:231 (1957).

    Article  Google Scholar 

  10. Hughes, A.F.W. Aspects of neural ontogeny, Logos Press (1968).

    Google Scholar 

  11. Trinkaus, J.P. Cells into Organs, Prentice Hall (1969).

    Google Scholar 

  12. Saunders, J.W. Science 154:604 (1966).

    Article  PubMed  Google Scholar 

  13. Lents, R.D., and Lapham, L.W. J.Neurochem.16:379 (1969).

    Article  Google Scholar 

  14. Giuditta, A. et al. Brain Res., in press.

    Google Scholar 

  15. Sandritter, W. et al. Z. Zellforsch. 80:145 (1967).

    Article  PubMed  CAS  Google Scholar 

  16. Mandel, P. et al. in Comparative Neurochemistry (Ed. D. Richter) p.149, Pergamon Press (1964).

    Google Scholar 

  17. Rappoport, D.A. et al. in Handbook of Neurochemistry vol.1, p.101 (Ed. A. Lajtha) Plenum Press (1969)

    Google Scholar 

  18. Dingman, C.W., and Sporn, M.B. J. Biol. Chem 239:3483 (1964).

    CAS  Google Scholar 

  19. Kurtz, D.I., and Sinex, P.M. Biochim. Biophys. Acta 145:840 (1967).

    PubMed  CAS  Google Scholar 

  20. Margolis, F.L. J. Neurochem. 26:447 (1969).

    Article  Google Scholar 

  21. Mori, K. J. Neurochem. 27:835 (1970).

    Article  Google Scholar 

  22. Hughes, A. J. embryol. exper. Morphol. 3:305 (1955).

    Google Scholar 

  23. Hughes, A., and Flexner, L.B. J. Anat. 90:386 (1956).

    PubMed  CAS  Google Scholar 

  24. Hyden, H. Acta Physiol. Scand. 6,Suppl.17:1 (1943).

    Google Scholar 

  25. Sensenbrenner, M., and Mandel, P. Z.Zellforsch. 82:65 (1967).

    Article  PubMed  CAS  Google Scholar 

  26. Adams, D.H., and Fox, M.E. Brain Res. 21:157 (1969).

    Article  Google Scholar 

  27. Dellweg, H. et al. J. Neurochem.15:1109 (1968).

    Article  PubMed  CAS  Google Scholar 

  28. Yamagami, S., and Mori, K. J.Neurochem. 17:721 (1970).

    Article  PubMed  CAS  Google Scholar 

  29. Bernsohn, J., and Norgello, H. Proc. Soc. Exp. Biol. Med. 122:22 (1966).

    PubMed  CAS  Google Scholar 

  30. Ringborg, U. Brain Res. 2:296 (1966).

    Article  PubMed  CAS  Google Scholar 

  31. Sharma, S.K., and Singh, U.N. J.Neurochem. 17:305 (1970).

    Article  PubMed  CAS  Google Scholar 

  32. Adams, D.H. Biochem, J. 98:636 (1966).

    CAS  Google Scholar 

  33. Brown, D.D., and Gurdon, J.B. Proc. Natl. Acad. Sci.US 51:669 (1964).

    Article  Google Scholar 

  34. Vesco, C., and Giuditta, A. Biochim. Biophys. Acta 112:385 (1967).

    Google Scholar 

  35. Caldarera, C.M. et al. J. Neurochem. 16:309 (1969).

    Article  PubMed  CAS  Google Scholar 

  36. Johnson, T.C. J. Neurochem. 14:1075 (1967).

    Article  PubMed  CAS  Google Scholar 

  37. Orrego, F. J. Neurochem. 14:851 (1967).

    Article  CAS  Google Scholar 

  38. Guroff, G. et al. J. Neurochem. 15:489 (1968).

    Article  PubMed  CAS  Google Scholar 

  39. Barondes, S.H. J. Neurochem. 11:663 (1964).

    Article  PubMed  CAS  Google Scholar 

  40. Bondy, S.C., and Waelsch, H. Life Sci. 3:633 (1964).

    Article  PubMed  CAS  Google Scholar 

  41. Moscona, A.A., and Kirk, D.L. Science 148:519 (1965).

    Article  PubMed  CAS  Google Scholar 

  42. Brachet, J. in Comprehensive Biochemistry vol.28, p.23 Eds. M. Florkin and E.H. Stotz) Elsevier Publ.Co.(1967).

    Google Scholar 

  43. Kirk, D.L. Proc. Natl. Acad.Sci.54:1345 (1965).

    Article  PubMed  CAS  Google Scholar 

  44. Piddington, R. Devel. Biol. 16:168 (1967).

    Article  CAS  Google Scholar 

  45. Krawiec, L. et al. Brain Res. 15:209 (1969).

    Article  PubMed  CAS  Google Scholar 

  46. Smith, E.L. et al. Physiol.Rev. 50:159 (1970).

    PubMed  CAS  Google Scholar 

  47. Ursprung, H., and Huang, R.C. Progr. Biophys. Mol. Biol. 17:151 (1967).

    Article  Google Scholar 

  48. Britten, R.J., and Davidson, E.H. Science 165:349 (1969).

    Article  PubMed  CAS  Google Scholar 

  49. Scarano, E. Ann. Embryol. Morphog.,Suppl. 1:51 (1969).

    Google Scholar 

  50. Gurdon, J.B., and Woodland, H.R. Biol.Rev. 43:233 (1968).

    Article  PubMed  CAS  Google Scholar 

  51. Davidson, E.H. et al. Proc. Natl. Acad. Sci.US 54:696 (1965).

    Article  CAS  Google Scholar 

  52. Crippa, M. Nature in press.

    Google Scholar 

  53. Tocchini-Valentini, G.P., and Crippa, M. Cold Spring Harbor Symp. Quant. Biol. 35 (1970) in press.

    Google Scholar 

  54. Burgess, R.R. et al. Nature 221:43 (1969).

    Article  PubMed  CAS  Google Scholar 

  55. Seeds, N.W. et al. Proc. Natl. Acad. Sci. US 65:160 (1970).

    Article  Google Scholar 

  56. Levi-Montalcini, R., and Angeletti, P. Phsyiol. Rev. 48:534 (1968).

    CAS  Google Scholar 

  57. Levi-Montalcini, R. et al. Brain Res. 12:54 (1969).

    Article  PubMed  CAS  Google Scholar 

  58. Toschi, G. et al. J. Neurochem. 13:539 (1966).

    Article  PubMed  CAS  Google Scholar 

  59. Riesen, A.H. in Prog. in Physiological Psychology p.117 Academic Press (1966).

    Google Scholar 

  60. Gyllenstein, L. et al. J.Comp.Neurol.126:463 (1966).

    Article  Google Scholar 

  61. White, R.H. J. Exp. Zool. 166:405 (1967).

    Article  CAS  Google Scholar 

  62. Hubel, D.H. Physiologist 10:17 (1967).

    PubMed  CAS  Google Scholar 

  63. Margolis, F.L., and Bondy, S.C. Exp.Neurol.27:353 (1970).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. International Institute of Genetics and Biophysics, Naples, Italy

    A. Giuditta

Authors
  1. A. Giuditta
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Pharmacology and Pharmacognosy, University of Milan, Italy

    Rodolfo Paoletti (Chairman) (Chairman)

  2. Department of Biochemistry, Charing Cross Hospital Medical School, University of London, UK

    Alan N. Davison (Professor of Biochemistry) (Professor of Biochemistry)

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Giuditta, A. (1971). Role of Nucleic Acids in Brain Development. In: Paoletti, R., Davison, A.N. (eds) Chemistry and Brain Development. Advances in Experimental Medicine and Biology, vol 13. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-7236-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-7236-3_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-7238-7

  • Online ISBN: 978-1-4684-7236-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation