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Methods for Measuring Indolealkylamine and Catecholamine Turnover Rate “In Vivo”

  • E. Costa
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 13)

Abstract

Many theoretical and practical problems are encountered in designing methods to calculate turnover rates of neuronal catecholamines and serotonin “in vivo.” The great majority of these difficulties derives from our incomplete understanding of the morphology and biochemistry of monoaminergic nerves. Frequently we circumvent the barriers of our ignorance by over simplifications leading to the formulation of kinetic models. Not only are these models unsatisfactory because of the implicit assumptions but as listed in Table 1, other limitations impair the in vivo measurements of turnover rates of brain monoamines in animals. Of course, the difficulties become insurmountable if we try to measure turnover rates of brain monoamines in man.

Keywords

Tyrosine Hydroxylase Turnover Rate Brain Monoamine Constant Rate Infusion Neuronal Monoamine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • E. Costa
    • 1
  1. 1.Laboratory of Preclinical Pharmacology, National Inst. of Mental HealthSaint Elizabeths HospitalUSA

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