Higher Plant Alkaloids, Amides, and Ansa Macrolides
A majority of the biosynthetic products with substantial activity against solid neoplastic disease contain one or more basic or nearly neutral nitrogen atoms. About 15 of these compounds are either now in clinical trial as cancer chemotherapeutic drugs or are being considered for such application. The discussion of this section will be centered primarily on these promising candidates for cancer treatment. A comparable number of nitrogen-containing anticancer agents (usually classed as antitumor antibiotics) from the lower plants will be found in the following chapter dealing with microorganism biosynthetic products.
KeywordsTotal Synthesis Antineoplastic Activity Quinoline Alkaloid Biosynthetic Product Nitidine Chloride
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