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Quinones, Flavans, and Other Nonnitrogenous Higher Plant Products

  • George R. Pettit

Abstract

All of the miscellaneous plant products ranging from hydrocarbons to the highly oxygenated polysaccharides have been grouped into this chapter. In general they have shown only marginal cytotoxic and/or in vivo antitumor properties. The gallic acid that we found to be the cytotoxic constituent of two Utah plants, Rhus trilobata (Anacardiaceae) and Oenothera caespitosa (Onagraceae), seems to be the smallest molecular-weight natural product so far isolated with those properties.323 A substance of comparable size with in vivo anticancer activity is crotepoxide (95), reported by Kupchan218 to be the antineoplastic agent of Croton macrostachys Höchst, ex. A. Rich (Euphorbiaceae). Cyclohexane diepoxide 95 was found to have activity against the LL system at a toxic dose and also to show inhibition of the WM tumor system. From a biogenetic viewpoint, crotepoxide seems related to shikimic acid. Ichihara and co-workers288 have completed a total synthesis of (±) crotepoxide.

Keywords

Gallic Acid Antineoplastic Agent Shikimic Acid Total Synthesis Aristolochic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • George R. Pettit
    • 1
  1. 1.Arizona State UniversityTempeUSA

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