Plant species of the Berberidaceae family, particularly from the Berberis and Epimedium genera, have been used in the treatment of warts and various solid tumors in China and India from at least the second century A.D.145 Another member of this family, Podophyllum peltatum L., commonly known as the may apple or mandrake, has been used for similar purposes in the United States from at least the 18th century. Perhaps the earliest use of this plant was by the Penobscot Indians of Maine. The alcohol-soluble portion from the dried roots and rhizomes is known as podophyllum, a material that appeared in the U.S. Pharmacopoeia from 1820 to 1942.301


Sesquiterpene Lactone Cinnamyl Alcohol Central Nervous System Cancer Biosynthetic Product Nervous System Cancer 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • George R. Pettit
    • 1
  1. 1.Arizona State UniversityTempeUSA

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