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Protection of Thiols

  • R. G. Hiskey
  • V. R. Rao
  • W. G. Rhodes

Abstract

The presence of cysteine and cystine residues in many polypeptides of natural origin and the importance of these residues as either components of an ‘active site’ or in the stabilization of the native conformation of the molecule has closely aligned the development and use of sulphur protective groups with the chemical synthesis of polypeptides. This chapter will therefore deal primarily with the protection of cysteine residues and the means by which cysteine residues may be deblocked and converted to cystine or retained as the thiol.

Keywords

Trifluoroacetic Acid Hydrogen Fluoride Protective Group Related Derivative Hydrogen Bromide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Company Ltd 1973

Authors and Affiliations

  • R. G. Hiskey
    • 1
  • V. R. Rao
    • 1
  • W. G. Rhodes
    • 1
  1. 1.Department of ChemistryThe University of North CarolinaChapel HillUSA

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