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Abstract

Primary and secondary amines are very susceptible to oxidation and to replacement reactions involving the N-H bonds, thus in order to keep an amino group intact throughout reactions involving other parts of the molecule it is usually necessary to protect these bonds by easily removable groups, of which there is a wide choice. The practice of amino group protection has been reviewed previously [1–3] and there have been numerous specialist reviews [4–8] and reports [9, 10] on the protection of amino groups in peptide synthesis. Most of the studies on the relative merits of known protective groups and the search for new, more effective ones have taken place in the area of peptide synthesis. However, the use of these groups for other purposes will be indicated as far as possible by the examples given in the subsequent sections of this chapter.

Keywords

Schiff Base Secondary Amine Peptide Synthesis Diethyl Malonate Tetrahedron Letter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Company Ltd 1973

Authors and Affiliations

  • J. W. Barton
    • 1
  1. 1.School of ChemistryUniversity of BristolBristolEngland

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