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Expression of Recombinant Human FSH, LH, and CG in Mammalian Cells: A Model for Probing Functional Determinants

  • I. Boime
  • J. Keene
  • A. B. Galway
  • F. A. M. Fares
  • P. LaPolt
  • A. J. W. Hsueh
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

The family of glycoprotein hormones includes pituitary thyrotropin (TSH), lutropin (LH), and follitropin (FSH) and placental chorionic gonadotropin (CG). TSH is critical for the maintenance of thyroid function; LH and FSH are needed for normal gonadal function, and CG is important for sustaining the corpus luteum during pregnancy. Each hormone is a heterodimer of 2 noncovalently associated subunits, α and β, that are encoded by separate genes located on different chromosomes in humans. The β-subunit confers the unique biological specificity for each hormone. Newly synthesized α -and β-subunits are rapidly assembled in the endoplasmic reticulum, and the oligosaccharides in the dimers undergo hormone-specific posttranslational modifications. Thus, the biological activity of these glycoprotein hormones can be regulated at several steps in the biosynthetic/secretory pathway.

Keywords

Sialic Acid Chinese Hamster Ovary Chorionic Gonadotropin Glycoprotein Hormone Affect Signal Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • I. Boime
  • J. Keene
  • A. B. Galway
  • F. A. M. Fares
  • P. LaPolt
  • A. J. W. Hsueh

There are no affiliations available

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