Estradiol Inhibition of Expression of the Human Glycoprotein Hormone α-Subunit Gene Through an ERE-Independent Mechanism

  • Ruth A. Keri
  • Bogi Andersen
  • Giulia C. Kennedy
  • Debora L. Hamernik
  • John H. Nilson
Part of the Serono Symposia USA book series (SERONOSYMP)


The α-subunit comprises one-half of all glycoprotein hormones. Expression of the α-subunit gene occurs in a variety of cell types (gonadotrophs, thyrotrophs, and syncytiotrophoblasts) and is regulated by a multitude of hormones, including gonadotropin releasing hormone (GnRH), thyrotropin releasing hormone (TRH), estradiol, thyroxine, and others. Thus, this gene serves as a useful model to study various mechanisms underlying hormonal regulation and cell-specific expression. In this report we focus on the approaches we have used to characterize the cis-acting elements required for placenta- and pituitary-specific expression and hormonal responsiveness of the α-subunit gene.


Flank Region Estrogen Response Element Chloramphenicol Acetyl Transferase Glycoprotein Hormone Human Estrogen Receptor 
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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Ruth A. Keri
  • Bogi Andersen
  • Giulia C. Kennedy
  • Debora L. Hamernik
  • John H. Nilson

There are no affiliations available

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