Secretion Pattern of FSH in Patients Suffering from Chorionic Gonadotropin-Producing Tumors
Intrinsic human follicle stimulating hormone (hFSH) activity (FSA) of human chorionic gonadotropin (hCG) has been proposed for many years (1). FSA was demonstrated in extracts of pregnancy urine and crude or highly purified hCG preparations. Whether FSA is due to cross-contamination of these hormone preparations with hFSH or represents “true” FSA is still a matter of debate. Studies employing immunoprecipitation techniques with polyclonal antisera suggest that the latter is more likely (2). These studies have been carried out using hormone standard preparations of various origin. So far, no investigations have been performed with pregnancy- and tumorderived sera containing high concentrations of hCG.
KeywordsHuman Chorionic Gonadotropin Testicular Cancer Secretion Pattern Glycoprotein Hormone Radioreceptor Assay
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