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Secretion Pattern of FSH in Patients Suffering from Chorionic Gonadotropin-Producing Tumors

  • P. Berger
  • S. Madersbacher
  • R. Klieber
  • G. Wick
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Intrinsic human follicle stimulating hormone (hFSH) activity (FSA) of human chorionic gonadotropin (hCG) has been proposed for many years (1). FSA was demonstrated in extracts of pregnancy urine and crude or highly purified hCG preparations. Whether FSA is due to cross-contamination of these hormone preparations with hFSH or represents “true” FSA is still a matter of debate. Studies employing immunoprecipitation techniques with polyclonal antisera suggest that the latter is more likely (2). These studies have been carried out using hormone standard preparations of various origin. So far, no investigations have been performed with pregnancy- and tumorderived sera containing high concentrations of hCG.

Keywords

Human Chorionic Gonadotropin Testicular Cancer Secretion Pattern Glycoprotein Hormone Radioreceptor Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Albert A. Follicle stimulating activity of human chorionic gonadotropin. J Clin Endocrinol Metab 1969; 29: 1504–9.PubMedCrossRefGoogle Scholar
  2. 2.
    Siris ES, Nisula BC, Catt KJ, et al. New evidence for intrinsic follicle-stimulating hormone-like activity in human chorionic gonadotropin and luteinizing hormone. Endocrinology 1978; 102: 1356–61.PubMedCrossRefGoogle Scholar
  3. 3.
    Berger P, Panmoung W, Khashabi D, Mayregger B, Wick G. Antigenic features of human follicle stimulating hormone delineated by monoclonal antibodies and construction of an immunoradiometric assay. Endocrinology 1988; 123: 2351–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Kofler R, Berger P, Wick G. Monoclonal antibodies against hCG, I. Production, specificity and intramolecular binding sites. Am J Reprod Immunol 1982; 160: 212–6.Google Scholar
  5. 5.
    Schwarz S, Berger P, Nelboeck E, et al. Probing the receptor interaction of glycoprotein hormones with monoclonal antibodies. J Recept Res 1988; 8: 437–53.PubMedGoogle Scholar
  6. 6.
    Berger P, Klieber R, Panmoung W, Madersbacher S, Wolf H, Wick G. Monoclonal antibodies against the free subunits of human chorionic gonadotropin. J Endocrinol 1990; 125: 301–9.PubMedCrossRefGoogle Scholar
  7. 7.
    De Jong FH. Inhibin. Physiol Rev 1988; 68: 555–607.PubMedGoogle Scholar
  8. 8.
    Morris PL, Vale WW, Cappel S, Bardin CW. Inhibin production by primary Sertoli cell-enriched cultures: regulation by follicle-stimulating hormone, androgens, and epidermal growth factor. Endocrinology 1988; 122: 717–25.PubMedCrossRefGoogle Scholar
  9. 9.
    Fingschedt U, Mann K, Clemm C, Nieschlag E. Elevated inhibin levels in patients with malignant teratomas [Abstract]. In: Proc 72nd annu meet Endocr Soc. Atlanta: Endocrine Society, 1990: 167.Google Scholar
  10. 10.
    McLachlan RI, Finkel DM, Bremner WJ, Snyder PJ. Serum inhibin concentrations before and during gonadotropin treatment in men with hypogonadotropic hypogonadism: physiological and clinical implication. J Clin Endocrinol Metab 1990; 70: 1414–9.PubMedCrossRefGoogle Scholar
  11. 11.
    McNeilly A. The control of FSH-secretion. Acta Endocrinol 1988; 288: 31–40.Google Scholar
  12. 12.
    Mann K, Schneider N, Hörmann R. Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophoblastic tumors. Endocrinology 1986; 118: 1558–66.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • P. Berger
  • S. Madersbacher
  • R. Klieber
  • G. Wick

There are no affiliations available

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