Basal Gonadotropins in Regularly Menstruating Women: Age-Related Changes in Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) Prior to the Perimenopause

  • N. A. Ahmed-Elabbiary
  • E. A. Lenton
  • I. D. Cooke
  • D. Wright
Part of the Serono Symposia USA book series (SERONOSYMP)


The traditional marker of reproductive senescence in women is the menopause, characterized by the loss of menstrual or fertility cycles at midlife. The female climacteric is based primarily on the loss of ovarian function. It has been suggested that a gradual rise in FSH levels appears to be the first detectable endocrine manifestation of reproductive aging (1). However, most investigators reported a rise in FSH and, later, LH levels after the age of 40 years (2, 3) or even after the age of 45 (4). In these reports, investigators reported this rise in FSH as a marker of the menopausal transition that consequently reflects “a state of partial ovarian failure,” which proceeds the actual menopause and loss of reproductive functions. Unlike women, healthy old men do experience a rise in FSH and LH later in life, but to a lesser degree than do postmenopausal women, despite the absence of gonadal failure or changes in plasma testosterone (T) (5, 6).


Luteinizing Hormone Follicle Stimulate Hormone Luteinizing Hormone Level Menopausal Transition Luteinizing Hormone Surge 
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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • N. A. Ahmed-Elabbiary
  • E. A. Lenton
  • I. D. Cooke
  • D. Wright

There are no affiliations available

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