Modulation of Gonadotropin and Sex Steroid Levels by Adrenal Androgens with Osmotic Pumps

  • Wlodzimierz Kowalski
  • Robert T. ChattertonJr.
Part of the Serono Symposia USA book series (SERONOSYMP)


Chronic exposure to an excess of adrenal androgens has been linked to the pathophysiology and the clinical picture of such endocrinological disorders as polycystic ovary syndrome (1), congenital adrenal hyperplasia (2), and hirsutism (3), conditions often associated with impaired fertility. The purpose of our study was to investigate subacute effects of elevated adrenal androgen levels on gonadotropin secretion and sex steroid concentrations in female monkeys. Of all adrenal androgens, dehydroepiandrosterone sulfate (DS) is the most abundant in the circulation, has the lowest metabolic clearance rate, and can be converted in vivo to other adrenal androgens (4). For these reasons, this steroid was chosen as a model for studying the influence of adrenal hyperandrogenaemia on the hormones of the pituitary-ovarian axis.


Luteal Phase Polycystic Ovary Syndrome Congenital Adrenal Hyperplasia Follicular Phase Adrenal Androgen 
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Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Wlodzimierz Kowalski
  • Robert T. ChattertonJr.

There are no affiliations available

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