Expression of FSH and LH Receptor mRNAs in the Rat Ovary

  • Tamara A. Camp
  • Kelly E. Mayo
Part of the Serono Symposia USA book series (SERONOSYMP)


The pituitary gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH), play important roles in regulating the steroidogenic and gametogenic functions of the gonads. The actions of these hormones are mediated by specific cell-surface receptors, the LH/hCG receptor (LH/hCGR), and the FSH receptor (FSH-R). Cloned cDNAs for these receptors were recently isolated in several laboratories (1–4). The deduced amino acid sequences of these two receptors predicts 7 potential transmembrane domains, indicating that they are related to the G-protein-coupled receptor family.


Granulosa Cell Thecal Cell Follicle Stimulate Hormone Receptor Degenerate Oligonucleotide Primer Testicular Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    McFarland KC, Sprengel R, Phillips HS, et al. Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science 1989; 245: 494–9.PubMedCrossRefGoogle Scholar
  2. 2.
    Sprengel R, Braun T, Nikolics K, Segaloff DL, Seeburg PH. The testicular receptor for follicle stimulating hormone: structure and functional expression of cloned cDNA. Mol Cell Endocrinol 1990; 4: 525–30.CrossRefGoogle Scholar
  3. 3.
    LaPolt PS, Oikawa M, Jia X, Dugan C, Hsueh AJW. Gonadotropin-induced up-and down-regulation of rat ovarian LH receptor message levels during follicular growth, ovulation, and luteinization. Endocrinology 1990; 6: 3277–9.CrossRefGoogle Scholar
  4. 4.
    Loosfelt H, Misrahi M, Atger M, et al. Cloning and sequencing of porcine LHhCG receptor cDNA: variants lacking transmembrane domain. Science 1989; 245: 525–7.PubMedCrossRefGoogle Scholar
  5. 5.
    Libert F, Parmentier M, Lefort A, et al. Selective amplification and cloning of four members of the G protein-coupled receptor family. Science 1989; 244: 569–72.PubMedCrossRefGoogle Scholar
  6. 6.
    Woodruff TK, Meunier H, Jones PB, Hsueh JW, Mayo KE. Rat inhibin: molecular cloning of a-and 13-subunit complementary deoxyribonucleic acids and expression in the ovary. Mol Cell Endocrinol 1987; 1: 561–8.CrossRefGoogle Scholar
  7. 7.
    Suter ST, Rahal JO, Mayo KE. Mouse growth hormone-releasing hormone: precursor structure and expression in brain and placenta. Mol Cell Endocrinol 1989; 3: 1693–700.CrossRefGoogle Scholar
  8. 8.
    Zeleznik AJ, Midgley AR, Reichert AR, Jr. Granulosa cell maturation in the rat: increased binding of human chorionic gonadotropin following treatment with follicle-stimulating hormone in vivo. Endocrinology 1974; 95: 818–25.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Tamara A. Camp
  • Kelly E. Mayo

There are no affiliations available

Personalised recommendations