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Purification and Characterization of Recombinant Human Follicle Stimulating Hormone

  • Glenn M. Smith
  • Leonora A. Bishop
  • Robert DeKroon
  • Greg Wright
  • Anne Cerpa-Poljak
  • Peter R. Schofield
Part of the Serono Symposia USA book series (SERONOSYMP)

Abstract

Follicle stimulating hormone (FSH) plays a major role in the maturation of ovarian follicles. FSH, a member of the glycoprotein hormone family produced in the anterior pituitary, is a 32-kD heterodimer consisting of 2 noncovalently linked subunits, α and β. Each subunit contains 2 asparagine-linked carbohydrate complexes that are required for full biological activity of the hormone (e.g., metabolic clearance rate, signal transduction, etc.). Variation in glycosylation patterns at these sites results in multiple hormone isoforms that possess differing biological activities.

Keywords

Sialic Acid Follicle Stimulate Honnone Metabolic Clearance Rate Recombinant Follicle Stimulate Honnone Human Follicle Stimulate Honnone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Schofield PR,Cerpa-Poljak A, Albrecht MF, Stuart MC, Hort YJ. Biological activities of recombinant human follicle stimulating hormone, Serono Symposia, USA. (See Chapter 30, this volume.)Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Glenn M. Smith
  • Leonora A. Bishop
  • Robert DeKroon
  • Greg Wright
  • Anne Cerpa-Poljak
  • Peter R. Schofield

There are no affiliations available

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