Purification and Characterization of Recombinant Human Follicle Stimulating Hormone
Follicle stimulating hormone (FSH) plays a major role in the maturation of ovarian follicles. FSH, a member of the glycoprotein hormone family produced in the anterior pituitary, is a 32-kD heterodimer consisting of 2 noncovalently linked subunits, α and β. Each subunit contains 2 asparagine-linked carbohydrate complexes that are required for full biological activity of the hormone (e.g., metabolic clearance rate, signal transduction, etc.). Variation in glycosylation patterns at these sites results in multiple hormone isoforms that possess differing biological activities.
KeywordsSialic Acid Follicle Stimulate Honnone Metabolic Clearance Rate Recombinant Follicle Stimulate Honnone Human Follicle Stimulate Honnone
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- 1.Schofield PR,Cerpa-Poljak A, Albrecht MF, Stuart MC, Hort YJ. Biological activities of recombinant human follicle stimulating hormone, Serono Symposia, USA. (See Chapter 30, this volume.)Google Scholar